First Irish birth following IVF therapy using antagonist protocol

Background During in vitro fertilization (IVF), the prevention of a premature LH surge was traditionally achieved using a gonadotrophin releasing hormone agonist (GnRH-a), and more recently, a GnRH antagonist. Aims We report a case of a 37 year old treated using the GnRH antagonist in a second completed cycle of IVF.

IVF was performed for primary infertility of 5-year duration due to frozen pelvis secondary to endometriosis.

Following controlled ovarian hyperstimulation, oocyte recovery and fertilization, cleavage and transfer of two zygotes, a pregnancy established. A twin gestation was diagnosed at 7-weeks scan and pregnancy ended with the delivery of twin girls by emergency caesarean section.

This is a first report of a delivery following IVF using the antagonist protocol in Ireland. Such therapy is patient friendly and its use should be introduced on a larger scale in clinical practice. Similar content being viewed by others

Albano C, Smitz J, Camus M (1997) Comparison of different doses of gonadotrophin-releasing hormone antagonist cetrorelix during controlled ovarian hyperstimulation. Fertil Steril 67:917–922 Mocanu E, Redmond ML, Hennelly B, Collins C, Harrison R (2007) Odds of ovarian hyperstimulation syndrome (OHSS)—time for reassessment. Hum Fertil (Camb) 10(3):175–181 Qublan HS, Amarin Z, Tahat YA, Smadi AZ, Kilani M (2006) Ovarian cyst formation following GnRH agonist administration in IVF cycles: incidence and impact. Hum Reprod 21(3):640–644 Steptoe PC, Edwards RG (1978) Birth after the reimplantation of a human embryo. Lancet 2(8085):366 Hamori M, Stuckensen JA, Rumpf D, Kniewald T, Kurz CS (1987) Premature luteinization of follicles during ovarian stimulation for in-vitro fertilization. Hum Reprod 2(8):639–643 Mettler L, Argiriou C, Abd-el Maeboud K, Steinmuller H, Semm K (1988) Ovulation induction for in-vitro-fertilization and embryo transfer applying decapeptyl (DTRP-6 LH/RH) in combination with HMG or FSH. Exp Clin Endocrinol 92(3):245–251 Katayama KP, Roesler M, Gunnarson C, Stehlik E, Jagusch S (1988) Short-term use of gonadotropin-releasing hormone agonist (leuprolide) for in vitro fertilization. J In Vitro Fertil Embryo Transf 5(6):332–334 Nelson LR, Fujimoto VY, Jaffe RB, Monroe SE (1995) Suppression of follicular phase pituitary-gonadal function by a potent new gonadotrophin-releasing hormone antagonist with reduced histamine-releasing properties (ganirelix). Fertil Steril 63:963–969 Tarlatzis BC, Fauser BC, Kolibianakis EM, Dietrich K (2006) GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update 12(4):333–340 Al-Inany HG, Abou-Setta AM, Aboulghar M (2006) Gonadotrophin-releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev 3:CD001750 Al-Inany HG, Aboulghar M, Mansour R, Serour GI (2005) Optimizing GnRH antagonist administration: meta-analysis of fixed vs. flexible protocol. Reprod Biomed Online 10:567–570 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Mocanu, E.V., Kondaveeti, N., Kelly, J. et al. First Irish birth following IVF therapy using antagonist protocol. Ir J Med Sci 179, 455–457 (2010). https://doi.org/10.1007/s11845-009-0336-2 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s11845-009-0336-2