{"paper_id":"af2a38c7-2b7c-49db-8687-8958a8aab84c","body_text":"Abstract\nBackground\nDuring in vitro fertilization (IVF), the prevention of a premature LH surge was traditionally achieved using a gonadotrophin releasing hormone agonist (GnRH-a), and more recently, a GnRH antagonist.\nAims\nWe report a case of a 37 year old treated using the GnRH antagonist in a second completed cycle of IVF.\nMethods\nIVF was performed for primary infertility of 5-year duration due to frozen pelvis secondary to endometriosis.\nResults\nFollowing controlled ovarian hyperstimulation, oocyte recovery and fertilization, cleavage and transfer of two zygotes, a pregnancy established. A twin gestation was diagnosed at 7-weeks scan and pregnancy ended with the delivery of twin girls by emergency caesarean section.\nConclusion\nThis is a first report of a delivery following IVF using the antagonist protocol in Ireland. Such therapy is patient friendly and its use should be introduced on a larger scale in clinical practice.\nSimilar content being viewed by others\nReferences\nAlbano C, Smitz J, Camus M (1997) Comparison of different doses of gonadotrophin-releasing hormone antagonist cetrorelix during controlled ovarian hyperstimulation. Fertil Steril 67:917–922\nMocanu E, Redmond ML, Hennelly B, Collins C, Harrison R (2007) Odds of ovarian hyperstimulation syndrome (OHSS)—time for reassessment. Hum Fertil (Camb) 10(3):175–181\nQublan HS, Amarin Z, Tahat YA, Smadi AZ, Kilani M (2006) Ovarian cyst formation following GnRH agonist administration in IVF cycles: incidence and impact. Hum Reprod 21(3):640–644\nSteptoe PC, Edwards RG (1978) Birth after the reimplantation of a human embryo. Lancet 2(8085):366\nHamori M, Stuckensen JA, Rumpf D, Kniewald T, Kurz CS (1987) Premature luteinization of follicles during ovarian stimulation for in-vitro fertilization. Hum Reprod 2(8):639–643\nMettler L, Argiriou C, Abd-el Maeboud K, Steinmuller H, Semm K (1988) Ovulation induction for in-vitro-fertilization and embryo transfer applying decapeptyl (DTRP-6 LH/RH) in combination with HMG or FSH. Exp Clin Endocrinol 92(3):245–251\nKatayama KP, Roesler M, Gunnarson C, Stehlik E, Jagusch S (1988) Short-term use of gonadotropin-releasing hormone agonist (leuprolide) for in vitro fertilization. J In Vitro Fertil Embryo Transf 5(6):332–334\nNelson LR, Fujimoto VY, Jaffe RB, Monroe SE (1995) Suppression of follicular phase pituitary-gonadal function by a potent new gonadotrophin-releasing hormone antagonist with reduced histamine-releasing properties (ganirelix). Fertil Steril 63:963–969\nTarlatzis BC, Fauser BC, Kolibianakis EM, Dietrich K (2006) GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update 12(4):333–340\nAl-Inany HG, Abou-Setta AM, Aboulghar M (2006) Gonadotrophin-releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev 3:CD001750\nAl-Inany HG, Aboulghar M, Mansour R, Serour GI (2005) Optimizing GnRH antagonist administration: meta-analysis of fixed vs. flexible protocol. Reprod Biomed Online 10:567–570\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nMocanu, E.V., Kondaveeti, N., Kelly, J. et al. First Irish birth following IVF therapy using antagonist protocol. Ir J Med Sci 179, 455–457 (2010). https://doi.org/10.1007/s11845-009-0336-2\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s11845-009-0336-2","source_license":"public-domain-us","license_restricted":false}