"Add-back" therapy for endometriosis in adolescents
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Adolescents with endometriosis refractory to conventional therapy may benefit from GnRH-a with add-back therapy, though ideal steroid dosages and long-term effects require further study.
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Abstract
OBJECTIVE: To review the impact of gonadotropin-releasing hormone agonists (GnRH-as) on bone mass in adolescents and options for GnRH-a with "add-back" for long-term therapy for adolescents with endometriosis not responding to conventional therapy.
STUDY DESIGN: Literature research.
RESULTS: The use of GnRH-a plus add-back therapy has not been specifically studied in the adolescent population, and thus the ideal dosage of add-back sex steroids for adolescents has not been delineated.
CONCLUSION: GnRH-a plus add-back can be considered for usage in adolescents with endometriosis who are refractory to conventional therapy, but steroids are needed to determine the ideal dosage and long-term effects.
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Cited by (11)
- Endometriosis in Adolescent Girls 2020
- Chronic pelvic pain and endometriosis 2019
- Chronic pelvic pain in children and adolescents 2013
- Dysmenorrhea in adolescents and young adults: an update on pharmacological treatments and management strategies 2012
- Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies 2008
- Endometriosis en la etapa infanto-juvenil: presentación de nueve casos en un hospital pediátrico 2007
- Dysmenorrhea in adolescents and young adults: etiology and management 2006
- Pelvic pain, ovarian cysts and endometriosis in adolescent girls 2004
- Adolescent endometriosis: diagnosis and treatment approaches 2003
- Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy 2003
- A contemporary approach to dysmenorrhea in adolescents 2002
Source provenance
- europepmc
- last seen: 2026-10-14T06:08:39.101224+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T22:00:35.617750+00:00
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