"Add-back" therapy for endometriosis in adolescents.

Jaqueline Neves Lubianca, J N Lubianca, Lubianca JN, Catherine M. Gordon, C M Gordon, Gordon CM, Laufer MR, Marc R. Laufer, M R Laufer
The Journal of reproductive medicine · 1998 · vol. 43(3) , pp. 164–72 · PMID:9564639 · W113943993
article OA: closed CC0 ⤵ 12 in-corpus citations
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Adolescents with endometriosis refractory to conventional therapy may benefit from GnRH-a with add-back therapy, though ideal steroid dosages and long-term effects require further study.

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Abstract

OBJECTIVE: To review the impact of gonadotropin-releasing hormone agonists (GnRH-as) on bone mass in adolescents and options for GnRH-a with "add-back" for long-term therapy for adolescents with endometriosis not responding to conventional therapy. STUDY DESIGN: Literature research. RESULTS: The use of GnRH-a plus add-back therapy has not been specifically studied in the adolescent population, and thus the ideal dosage of add-back sex steroids for adolescents has not been delineated. CONCLUSION: GnRH-a plus add-back can be considered for usage in adolescents with endometriosis who are refractory to conventional therapy, but steroids are needed to determine the ideal dosage and long-term effects.

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Condition tags

endometriosis

MeSH descriptors

Bone Density Endometriosis Estrogens Gonadotropin-Releasing Hormone Progestins Adolescent Adolescent Medicine Adolescent Medicine Bone Density Endometriosis Estrogen Replacement Therapy Estrogens Estrogens Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Health Behavior Humans Life Style

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (11)

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