Description of an endometrioid ovarian cancer cell line

Francesca R. Giancotti, F R Giancotti, B H Dorsett, Brent H. Dorsett, S C Weaver, Scott C. Weaver, Rajendra Bharathur, R Bharathur, Harry L. Ioachim, H L Ioachim, H R Barber, Hugh R.K. Barber
Gynecologic oncology · 1989 · doi:10.1016/0090-8258(89)90073-5 · PMID:2480932
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Abstract

A human cell line, designated L-1, has been established from the ascites of an untreated patient with stage IV (FIGO) endometrioid ovarian cancer. This cell line initially grew uninterupted for 6 months without fibroblast contamination and contact inhibition, and has been subcultured weekly for the past 7 years. L-1 does not contain steroid hormone receptors nor does it demonstrate the presence of oncofetal antigens by immunohistochemical techniques. The doubling time of L-1 is 11.8 hr. Flow cytometric analysis reveals an aneuploid DNA peak, and an abnormal karyotype demonstrates hyperdiploidy, translocations, and deletions. Morphology, growth patterns, cytogenetic analysis, and other features of L-1 are characterized.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms alpha-Fetoproteins alpha-Fetoproteins Carcinoembryonic Antigen Carcinoembryonic Antigen Cell Line Cell Transformation, Neoplastic Cell Transformation, Neoplastic Chromosomes Chromosomes Endometriosis Endometriosis Female Flow Cytometry Glycogen Glycogen Humans Immunohistochemistry Microscopy, Electron

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