Difficult management of abnormal uterine bleeding in Glanzmann thrombasthenia

Article Text Abstract Glanzmann thrombasthenia (GT) is a rare haematological disorder with abnormal platelet surface receptor glycoprotein IIb/IIIa, resulting in faulty platelet aggregation. Patients with GT may present with spontaneous bleeding after trauma or surgery. As the disease is rare, controlling and preventing bleeding in such patients is challenging. We report two cases of previously diagnosed GT presented with abnormal uterine bleeding. The first case was managed medically with tranexamic acid and hormonal therapy to control menstrual bleeding. In contrast, the second case involved a tubo-ovarian endometrioma presenting with heavy menstrual bleeding (HMB) and dysmenorrhoea, which was treated with laparoscopic adhesiolysis and cyst aspiration. Management of HMB and endometriosis is challenging, especially when using invasive procedures such as laparoscopy. Physicians should be familiar with the characteristics of the disease and all possible treatment options to halt the bleeding to avoid morbidity in patients. - Uterus - Obstetrics and gynaecology - Haematology (incl blood transfusion) Statistics from Altmetric.com Footnotes Contributors The following authors were directly involved in the patient’s care: MM, SS, SP and SRS. The following author is the clinician in charge of the clinical care of the patient, who supervised the preparation of the manuscript, was responsible for obtaining informed consent from the patient/guardian/family members and is responsible for the overall integrity of the content of the manuscript: SS. SS will act as the guarantor for the paper. Funding No funds have been utilized for this study. Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy. Competing interests None declared. Provenance and peer review Not commissioned; externally peer reviewed.