Endometriosis: identification by carbonic anhydrase autoantibodies and clinical features

D. A. Brinton, Brinton DA, Quattrociocchi-Longe TM, T M Quattrociocchi-Longe, Frederick L. Kiechle, F L Kiechle, Kiechle FL
Annals of clinical and laboratory science · 1997 · vol. 26(5) , pp. 409–20 · PMID:8879358 · W2428445668
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Carbonic anhydrase II autoantibodies combined with clinical features identify endometriosis, with higher antibody levels correlating with more advanced disease stages.

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Abstract

Reliably diagnosing endometriosis traditionally requires surgery. To evaluate a possible non-surgical method, a case-control series of unexplained infertility patients undergoing diagnostic laparoscopy were scored by clinical criteria and reactivity to human carbonic anhydrase II by Western blotting. The CA II autoantibodies were found in none of the fertile controls, 38 percent of infertile controls, 55 percent of stage 1, 50 percent of stage 2, 73 percent of stage 3, and 85 percent of stage 4 endometriosis patients. Advanced endometriosis was associated with more intense reactivity. Combining clinical and antibody scores for infertile groups showed a positive association with disease stage with positive predictive values of 76 to 95 percent, negative predictive values of 90 to 60 percent, and a likelihood ratio of 18.3. It is concluded by us that CA II immunoreactivity, clinical, and combined scores all identified stages 2 to 4 endometriosis patients. However, based on predictive values and likelihood ratios, the combined score is best at identifying endometriosis non-surgically.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Carbonic Anhydrases Endometriosis Endometriosis Immunologic Tests Immunologic Tests Adult Adult Autoantibodies Autoantibodies Carbonic Anhydrases Carbonic Anhydrases Endometriosis Endometriosis Endometriosis Female Female Humans Humans Laparoscopy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (7)

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human

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