Endometriosis increases the rate of spontaneous early miscarriage in women who have adenomyosis lesions

Mathilde Bourdon, Bourdon M, Benjamine Pham, Pham B, Marcellin L, Louis Marcellin, Corinne Bordonne, Bordonne C, Corinne Bordonné, A. Millischer, Anne Elodie Millischer, Millischer AE, Chloé Maignien, Maignien C, Piétro Santulli, Pietro Santulli, Charles Chapron, Chapron C
Reproductive biomedicine online · 2021 · vol. 44(1) , pp. 104–111 · doi:10.1016/j.rbmo.2021.10.003 · PMID:34819248 · W3205654509
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the impact of endometriosis on early miscarriage rates in women with adenomyosis lesions, finding that endometriosis exacerbates the risk of spontaneous early pregnancy loss.

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Abstract

Research questionIn women with radiologically diagnosed adenomyosis, is the presence of endometriosis associated with a higher rate of miscarriage?DesignAn observational cohort study of women who received medical care for benign gynaecological conditions between May 2005 and May 2018. Women who had adenomyosis lesions visualized by uterine magnetic resonance imaging (MRI) were included. Women who had never been pregnant were excluded. Women with adenomyosis identified by MRI but who did not have endometriosis lesions (control group) were compared with women with adenomyosis and endometriosis lesions (study group). Primary outcome was rate of a previous history of early miscarriage.ResultsA total of 214 pregnancies in the study group and 53 pregnancies in the control group were analysed. The rate of a previous miscarriage was significantly higher among women with adenomyosis and endometriosis lesions compared with women in the control group (61/214 [28.5%] versus 6/53 [11.3%], respectively, P = 0.009). A multivariable generalized estimating equation logistic regression model, adjusted for adenomyosis and endometriosis phenotypes, found that the association between endometriosis and adenomyosis significantly increased the risk of miscarriage (OR 3.2, 95% CI 1.1 to 9.65). The risk was significantly higher with deep infiltrating endometriosis (OR 4.37, 95% CI 1.32 to 14.53).ConclusionsWomen affected by endometriosis had a significantly higher rate of previous spontaneous miscarriage than women without endometriosis with adenomyosis lesions identified by MRI. Mechanistic studies are needed to establish the complex link between the presence of endometriosis and adenomyosis and the rate of spontaneous miscarriage.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Abortion, Spontaneous Abortion, Spontaneous Adenomyosis Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Female Humans Pregnancy Uterus Uterus

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