Editorial: Uterine factors associated with fertility impairment

This editorial in Frontiers in Endocrinology discusses uterine and endometrial factors relevant to infertility, highlighting multiple invited reviews and studies spanning endometriosis, adenomyosis, implantation failure, chronic endometritis, endometrial microbiome, and endocrine-disrupting chemicals. It summarizes findings including molecular reviews of endometriosis/adenomyosis, preclinical work in a murine endometriosis model using human adipose-derived stem cell conditioned medium, mechanistic adenomyosis data implicating IL-33–HOXA10 signaling via STAT3 and bromocriptine effects on endometrial proliferation/miRNAs, and clinical modeling of live birth prediction after frozen embryo transfer in adenomyosis. It also covers recurrent implantation failure research such as an RNA-sequencing-based endometrial receptivity test showing higher pregnancy rates, cytokine profiling patterns, limited differences with LMWH or selective timing of endometrial injury, and CE studies linking hypoxic/angiogenic dysregulation to reduced receptivity. A key limitation is that, as an editorial, it provides a narrative overview rather than a single original evidence base with standardized methods. This paper is centrally about endometriosis and adenomyosis—its focus is uterine/endometrial physiology and pathology and it explicitly highlights multiple endometriosis and adenomyosis studies, including mechanistic and clinical topics.

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