Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis.

Mina Amiri, Bidhendi-Yarandi R, Fallahzadeh A, Marzban Z, Ramezani Tehrani F
International journal of reproductive biomedicine · 2022 · doi:10.18502/ijrm.v20i11.12357 · PMID:36618838 · PMC9806243
OA: gold CC-BY-4.0
📄 Open PDF Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-24 ⓘ

This meta-analysis found that women with polycystic ovary syndrome have an increased risk of endometrial and ovarian cancers compared to controls, but no significant association with breast cancer.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-24 · read from full text ⓘ

This systematic review and meta-analysis evaluated the association between polycystic ovary syndrome (PCOS) and the risk of endometrial, ovarian, and breast cancers by pooling data from 14 observational studies. The results indicated that women with PCOS have a significantly higher risk of developing endometrial cancer and a moderately increased risk of ovarian cancer compared to controls, while no significant association was found for breast cancer. Although publication bias was detected and adjusted for in some analyses, the study noted high risks of bias in exposure assessment among included case-control studies. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

BackgroundAlthough several studies have evaluated the risk of gynecological cancers in women with polycystic ovary syndrome (PCOS), there are controversies regarding it.ObjectiveThis study aimed to investigate the association of PCOS with endometrial, ovarian, and breast cancers.Materials and methodsPubMed, Scopus, Web of Science, and Google Scholar databases based on MESH terms using the combination of the appropriate keywords were searched to retrieve observational studies on endometrial, ovarian, and breast cancers in PCOS women, published from inception to April 2020. This meta-analysis was performed to determine the pooled odds ratio (OR) of these cancers in women with PCOS. Publication bias was assessed by using Begg's test.ResultsOf 1347 records retrieved by searching the databases, a total of 14 articles were included in the study. Overall, the pooled OR of the composite outcome, including endometrial, ovarian, and breast cancers in women with PCOS was higher than that of women with no PCOS (pooled OR: 1.4, 95% CI: 1.0-1.9). The pooled OR of endometrial (pooled OR: 2.2, 95% CI: 1.03-4.7) and ovarian (pooled OR: 1.3, 95% CI: 1.0-1.8) cancers in women with PCOS was higher than the control group, whereas the pooled OR of breast cancer was not significantly higher than that of the control group.ConclusionThis meta-analysis indicated an increased risk of endometrial and ovarian cancers in women with PCOS.
Full text 21,436 characters · extracted from pmc-nxml · 2 sections · click to expand

Section

This study indicated the increased risk of endometrial and ovarian cancers in women with PCOS. Therefore, screening programs for early detection of these cancers, especially in women with PCOS, can be considered an important strategy for improving their survival.

Coi Statement

The authors have no conflict of interest to declare.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: pmc-nxml ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-10-04T09:26:46.659050+00:00
License: CC-BY-4.0 · commercial use OK · attribution required
Per Europe PMC