Pengaruh Pemberian Leuprolide Acetat Terhadap Kadar IL-17A pada Mencit Model Endometriosis

Ana Paramita Prastiwi, Merry Delyka, Chrisdianti Yulita, Dessy Hertati
In: Jurnal Surya Medika · 2024 · vol. 10(3) , pp. 105–108 · doi:10.33084/jsm.v10i3.8972 · W4406166730
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study investigated the effect of Leuprolide Acetate administration on IL-17A levels in a mouse model of endometriosis, finding that it influenced these levels.

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This study examined how administering leuprolide acetate affects IL-17A levels in a mouse model of endometriosis. Fifteen mice were divided into three groups—healthy controls, untreated endometriosis model mice, and endometriosis model mice treated with leuprolide acetate—and IL-17A was measured using ELISA. The authors report that leuprolide acetate had an effect on IL-17A levels in the endometriosis model mice. The paper does not explicitly describe additional limitations beyond the brief methods and abstract-level findings, and it does not provide details on magnitude of change or experimental parameters in the provided text. This paper is centrally about endometriosis — it specifically tests the effect of leuprolide acetate on IL-17A levels in endometriosis model mice.

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Abstract

Endometriosis adalah kelainan umum yang dikaitkan dengan nyeri, gejala gastrointestinal dan saluran kemih, infertilitas, dan kelelahan. Endometriosis didefinisikan oleh adanya lesi mirip endometrium yang sebagian besar ditemukan di panggul. Mekanisme yang berkontribusi terhadap etiologi penyakit ini meliputi perubahan jalur hormonal, inflamasi, dan nyeri IL-17A. Leuprolide Acetat adalah analog sintetik dari hormon pelepas gonadotropin (GnRH) yang terjadi secara alami, yang bertindak sebagai penghambat kuat sekresi gonadotropin hipofisis bila diberikan terus menerus pada dosis terapeutik. Penelitian ini bertujuan untuk melihat pengaruh pemberian Leuprolide Acetat terhadap Kadar IL-17A pada mencit model endometriosis. Sebanyak 15 ekor mencit di bagi menjadi 3 kelompok yaitu mencit sehat, mencit Endometriosis, mencit Endometriosis diberikan Leuprolide Acetat. Kadar IL-17A diukur dengan enzyme-linked immunosorbent assay (ELISA) pada masing-masing kelompok pengamatan. Dari hasil penelitian ini menunjukkan bahwa terdapat pengaruh pemberian Leuprolide Acetat terhadap kadar IL-17A pada mencit model endometriosis.
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Abstract

Endometriosis adalah kelainan umum yang dikaitkan dengan nyeri, gejala gastrointestinal dan saluran kemih, infertilitas, dan kelelahan. Endometriosis didefinisikan oleh adanya lesi mirip endometrium yang sebagian besar ditemukan di panggul. Mekanisme yang berkontribusi terhadap etiologi penyakit ini meliputi perubahan jalur hormonal, inflamasi, dan nyeri IL-17A. Leuprolide Acetat adalah analog sintetik dari hormon pelepas gonadotropin (GnRH) yang terjadi secara alami, yang bertindak sebagai penghambat kuat sekresi gonadotropin hipofisis bila diberikan terus menerus pada dosis terapeutik. Penelitian ini bertujuan untuk melihat pengaruh pemberian Leuprolide Acetat terhadap Kadar IL-17A pada mencit model endometriosis. Sebanyak 15 ekor mencit di bagi menjadi 3 kelompok yaitu mencit sehat, mencit Endometriosis, mencit Endometriosis diberikan Leuprolide Acetat. Kadar IL-17A diukur dengan enzyme-linked immunosorbent assay (ELISA) pada masing-masing kelompok pengamatan. Dari hasil penelitian ini menunjukkan bahwa terdapat pengaruh pemberian Leuprolide Acetat terhadap kadar IL-17A pada mencit model endometriosis. Downloads Article Details This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. All rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.

References

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