{"paper_id":"a5cea372-71dd-42c5-ab9d-e54a94a85e92","body_text":"Pengaruh Pemberian Leuprolide Acetat Terhadap Kadar IL-17A pada Mencit Model Endometriosis The Effect of Leuprolide Acetat On IL-17A Levels in Endometriosis Model Mice\nMain Article Content\nAbstract\nEndometriosis adalah kelainan umum yang dikaitkan dengan nyeri, gejala gastrointestinal dan saluran kemih, infertilitas, dan kelelahan. Endometriosis didefinisikan oleh adanya lesi mirip endometrium yang sebagian besar ditemukan di panggul. Mekanisme yang berkontribusi terhadap etiologi penyakit ini meliputi perubahan jalur hormonal, inflamasi, dan nyeri IL-17A. Leuprolide Acetat adalah analog sintetik dari hormon pelepas gonadotropin (GnRH) yang terjadi secara alami, yang bertindak sebagai penghambat kuat sekresi gonadotropin hipofisis bila diberikan terus menerus pada dosis terapeutik. Penelitian ini bertujuan untuk melihat pengaruh pemberian Leuprolide Acetat terhadap Kadar IL-17A pada mencit model endometriosis. Sebanyak 15 ekor mencit di bagi menjadi 3 kelompok yaitu mencit sehat, mencit Endometriosis, mencit Endometriosis diberikan Leuprolide Acetat. Kadar IL-17A diukur dengan enzyme-linked immunosorbent assay (ELISA) pada masing-masing kelompok pengamatan. Dari hasil penelitian ini menunjukkan bahwa terdapat pengaruh pemberian Leuprolide Acetat terhadap kadar IL-17A pada mencit model endometriosis.\nDownloads\nArticle Details\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nAll rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.\nReferences\nAhn, S. H., Edwards, A. K., Singh, S. S., Young, S. L., Lessey, B. A., & Tayade, C. 2015. IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. Journal of Immunology (Baltimore, Md. : 1950), 195(6), 2591–2600. https://doi.org/10.4049/jimmunol.1501138\nBarnard, N. D., Holtz, D. N., Schmidt, N., Kolipaka, S., Hata, E., Sutton, M., Znayenko-Miller, T., Hazen, N. D., Cobb, C., & Kahleova, H. 2023. Nutrition in the prevention and treatment of endometriosis: A review. Frontiers in Nutrition, 10. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1089891\nGriffiths, M. J., Horne, A. W., Gibson, D. A., Roberts, N., & Saunders, P. T. K. 2024. Endometriosis: recent advances that could accelerate diagnosis and improve care. Trends in Molecular Medicine, 30(9), 875–889. https://doi.org/10.1016/j.molmed.2024.06.008\nHarada, T., Osuga, Y., Suzuki, Y., Fujisawa, M., Fukui, M., & Kitawaki, J. 2022. Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain compared with leuprorelin in Japanese women: a phase 3, randomized, double-blind, noninferiority study. Fertility and Sterility, 117(3), 583–592. https://doi.org/10.1016/j.fertnstert.2021.11.013\nHorne, A. W., & Missmer, S. A. 2022. Pathophysiology, diagnosis, and management of endometriosis. BMJ (Clinical Research Ed.), 379, e070750. https://doi.org/10.1136/bmj-2022-070750\nHoseininasab, F., Mehrjardi, Y. V., Javaheri, A., Tajamolian, M., & Samadi, M. 2024. Study on gene expression of IL-17A in eutopic and ectopic tissue sample of endometriosis patients and comparison with control group. Biomedical Research and Therapy, 11(6), 6482–6487.\nKrina T. Zondervan, D.Phil., Christian M. Becker, M. D., & and Stacey A. Missmer, S. D. 2020. Endometriosis, Review Article. N Engl J Med, 382(1244), 56. https://doi.org/10.1056/NEJMra1810764\nMagon, N. 2011. Gonadotropin releasing hormone agonists: Expanding vistas. Indian Journal of Endocrinology and Metabolism, 15(4), 261–267. https://doi.org/10.4103/2230-8210.85575\nPrentice, A., Aj, D., Farquhar, C., & Sk, S. 2011. Gonadotrophin-releasing hormone analogues for pain associated with endometriosis: Commentary. Obstetrics and Gynecology, 117(3), 727–728. https://doi.org/10.1097/AOG.0b013e31820cb0fd\nShi, J. L., Zheng, Z. M., Chen, M., Shen, H. H., Li, M. Q., & Shao, J. 2022. IL-17: an important pathogenic factor in endometriosis. International Journal of Medical Sciences, 19(4), 769–778. https://doi.org/10.7150/ijms.71972\nSutrisno, S., Miryani, I., Dwijayasa, P. M., Suprobo, N. R., & Wiyasa, I. W. A. 2022. Genistein administration increases the level of superoxide dismutase and glutathione peroxidase in the endometriosis mice model: An experimental study. International Journal of Reproductive BioMedicine, 20(10), 873–882. https://doi.org/10.18502/ijrm.v20i10.12271\nZhou, W., Yang, H., Shao, J., Mei, J., Chang, K., Zhu, R., & Li, M. 2019. sitokin anti inflamasi pada endometriosis. 0123456789","source_license":"CC0","license_restricted":false}