Editorial: Androgen receptors in male and female reproduction.

Barbagallo F, D'Andrea S
Frontiers in endocrinology · 2025 · doi:10.3389/fendo.2025.1638220 · PMID:40607217 · PMC12213367
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This editorial discusses the roles of androgen receptors in both male and female reproduction without providing specific abstract details or findings.

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This editorial reviews the structural and functional roles of the androgen receptor in both male and female reproductive physiology, highlighting its involvement in conditions such as complete androgen insensitivity syndrome and polycystic ovary syndrome. The authors summarize recent studies demonstrating that androgen signaling influences folliculogenesis, ovarian reserve, and immune dysfunction within the context of hyperandrogenism, while also noting the potential for tissue-selective androgen modulators as therapeutic targets. Relevance to endometriosis: listed as a condition where AR antagonists could potentially mitigate excessive androgenic signaling, though the paper's main focus is broader reproductive health and PCOS.

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References

1 MatsumotoTKawanoHShiinaHSatoTKatoS. Androgen receptor functions in male and female reproduction. Reprod Med Biol. (2007) 6(1):11–7. doi: 10.1111/j.1447-0578.2007.00159.x 2 BarbagalloFCannarellaRBertelliMCrafaALa VigneraSCondorelliRAet al. Complete androgen insensitivity syndrome: from the relevance of an accurate genetic diagnosis to the challenge of clinical management. A Case Rep Medicina (Kaunas). (2021) 57:1142. doi: 10.3390/medicina57111142 3 MatsumotoTSakariMOkadaMYokoyamaATakahashiSKouzmenkoAet al. The androgen receptor in health and disease. Annu Rev Physiol. (2013) 75:201–24. doi: 10.1146/annurev-physiol-030212-183656 4 MatsumotoTShiinaHKawanoHSatoTKatoS. Androgen receptor functions in male and female physiology. J Steroid Biochem Mol Biol. (2008) 109(3–5):236–41. doi: 10.1016/j.jsbmb.2008.03.023 5 TsaiYRLiaoYNKangHY. Current advances in cellular approaches for pathophysiology and treatment of polycystic ovary syndrome. Cells. (2023) 12(17):2189. doi: 10.3390/cells12172189 6 DavisSRWahlin-JacobsenS. Testosterone in women: the clinical significance. Lancet Diabetes Endocrinol. (2015) 3:980–92. doi: 10.1016/S2213-8587(15)00345-2 Summary

Keywords

androgen, androgen recepter, male reproduction, female reproduction, PCOS (polycystic ovarian syndrome), reproductive tract Citation Barbagallo F and D’Andrea S (2025) Editorial: Androgen receptors in male and female reproduction. Front. Endocrinol. 16:1638220. doi: 10.3389/fendo.2025.1638220 Received 30 May 2025 Accepted 06 June 2025 Published 18 June 2025 Volume 16 - 2025 Edited and reviewed by Claus Yding Andersen, University of Copenhagen, Denmark Updates Copyright © 2025 Barbagallo and D’Andrea. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Settimio D’Andrea, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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