Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy

F G Varol, Füsun Varol, A M Duchemin, Anne‐Marie Duchemin, Norton H. Neff, N H Neff, Maria Hadjiconstantinou, M Hadjiconstantinou
Neuroscience letters · 2000 · vol. 294(1) , pp. 58–62 · doi:10.1016/s0304-3940(00)01533-0 · PMID:11044586 · W2052218259
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Nerve growth factor (NGF) and its messenger RNA (mRNA) levels were analyzed in the rat uterus throughout pregnancy to understand their role in uterine physiology.

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Abstract

During pregnancy, the uterus undergoes a profound sympathetic denervation. To explore whether this is associated with changes in neurotrophic factors, we assayed nerve growth factor (NGF) and NGF mRNA in the uterus of non-pregnant and pregnant rats. In the uterine horn, the concentration of NGF and its mRNA decreased during middle and late pregnancy. However, when values were corrected for the increase of uterine weight and total RNA yield during pregnancy, NGF content and mRNA per horn increased during middle and late pregnancy. Similar, but less pronounced, changes were observed in the cervix. By seven days postpartum, both parameters returned to near normal.

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MeSH descriptors

Nerve Growth Factor RNA, Messenger Uterus Animals Cervix Uteri Cervix Uteri Female Gestational Age Nerve Growth Factor Nerve Growth Factor Organ Size Pregnancy Rats RNA, Messenger Time Factors Uterus

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