The Clinical Efficacy of Gamete Intrafallopian Transfer by Minilaparotomy versus in vitro Fertilization and Embryo Transfer

Masaaki Sayama; Shigeo Araki; Mitsuhiro Motoyama; Taro Tamada; Ikuo Sato

doi:10.1111/j.1447-0756.1996.tb01049.x

The Clinical Efficacy of Gamete Intrafallopian Transfer by Minilaparotomy versus in vitro Fertilization and Embryo Transfer

Masaaki Sayama, Shigeo Araki, Mitsuhiro Motoyama, Taro Tamada, Ikuo Sato

In: Journal of Obstetrics and Gynaecology Research · 1996 · vol. 22(5) , pp. 409–416 · doi:10.1111/j.1447-0756.1996.tb01049.x · PMID:8987320 · W2013157523

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Abstract

OBJECTIVE: To evaluate the clinical performance of gamete intrafallopian transfer (GIFT) and in vitro fertilization and embryo transfer (IVF-ET). METHODS: Infertile women were divided into 2 groups: for GIFT, 239 patients (326 cycles) with at least 1 patent tube; and, for IVF-ET, 125 patients (210 cycles) with bilateral tubal occlusion. A specially designed retractor was developed to replace the gametes into an appropriate section of the Fallopian tube accurately and safely. Several parameters, including the pregnancy and delivery rates of each group, were compared. RESULTS: The success rate per trial in the GIFT group was approximately 1.5 times higher than that in the IVF group (pregnancy rate: 44.2% vs. 31.0%, p < 0.01; delivery rate: 33.4% vs. 22.9%, p < 0.01). The pregnancy and delivery rates of GIFT decreased steadily with the number of trials. These apparent decreases were not observed up to the 3rd trial in IVF-ET cases. CONCLUSIONS: GIFT with a minilaparotomy procedure yielded significantly higher success rates than IVF-ET. Accordingly, GIFT is considered to be the first treatment choice in infertility cases with at least 1 patent Fallopian tube.

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Does i.v. albumin prevent ovarian hyperstimulation syndrome? 1999

References (17)

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Cited by (1)

Does i.v. albumin prevent ovarian hyperstimulation syndrome? 1999

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[1] The relationship of tubal blockage, infertility of unknown cause, suspected male infertility, and endometriosis to success of in vitro fertilization and embryo transfer 1983

[2] Assisted fertilization in infertile women with patent Fallopian tubes. A comparison of in-vitro fertilization, gamete intra-Fallopian transfer and tubal embryo stage transfer 1990