Pregnancy outcomes in women with different endometriosis lesion types: A review of current evidence

Hrishikesh Munshi, Nayna Barada, Sandhya Anand, Rahul Gajbhiye
Journal of Obstetrics and Gynaecology Research · 2025 · vol. 51(5) , pp. e16321 · doi:10.1111/jog.16321 · PMID:40384629
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Endometriosis, especially ovarian and deep infiltrating types, is associated with increased risks of placenta previa, preterm birth, IUGR, and miscarriage, with ART conception further elevating these risks.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This paper is a systematic review of studies published from 2014 to 2025 examining how endometriosis lesion types relate to adverse maternal–fetal outcomes, using a comprehensive search across PubMed, Scopus, Google Scholar, and Web of Science and selecting 10 eligible studies. Across included evidence, endometriosis was associated with higher risks of placenta previa—especially in advanced-stage disease (Stages III–IV) and deep infiltrating endometriosis—along with increased preterm birth linked to bladder and rectal DIE but not ovarian endometriomas. The review also reports a moderate association with pre-eclampsia, more frequent IUGR/SGA with DIE and advanced stage, inconsistent findings for stillbirth, and higher miscarriage risk in superficial endometriosis compared with DIE or OMA, while noting the need for larger studies to clarify inconsistencies. This paper is centrally about endometriosis — it reviews how specific endometriosis lesion subtypes and stages relate to pregnancy outcomes.

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Abstract

BACKGROUND: Endometriosis, affecting ~10% of women of reproductive age, is associated with infertility and adverse pregnancy outcomes. The condition is classified into superficial peritoneal endometriosis (SUP), ovarian endometriomas (OMA), and deep infiltrating endometriosis (DIE), with varying impacts on pregnancy. This review examines the relationship between lesion subtypes and adverse maternal-fetal outcomes. METHODS: A comprehensive literature search was conducted using PubMed, Scopus, Google Scholar, and Web of Science. Studies published between 2014 and 2025 that investigated pregnancy outcomes in women with endometriosis were included. Articles were screened based on predefined inclusion criteria, with 10 studies meeting the final selection. Outcomes analyzed included placenta previa, preterm birth, stillbirth, pre-eclampsia, intrauterine growth restriction (IUGR), and miscarriage. RESULTS: Women with endometriosis exhibited a significantly higher risk of placenta previa, particularly those with Stages III-IV disease (p < 0.05) and deep infiltrating lesions (p < 0.05). The risk was further elevated in pregnancies conceived via assisted reproductive technologies (ART) (p = 0.01). The likelihood of preterm birth was higher in patients with bladder DIE (p = 0.02) and rectal DIE (p = 0.01), but not in those with ovarian endometriomas. Meta-analysis data indicated a moderate association between endometriosis and pre-eclampsia (p < 0.05), particularly in patients with deep lesions (p = 0.03). Stillbirth risk showed inconsistent findings, with some studies reporting an increased risk (p < 0.05) while others found no significant association. IUGR and small-for-gestational-age (SGA) infants were more common in women with DIE (p = 0.03) and advanced-stage disease (p = 0.05). Miscarriage risk was elevated in patients with superficial endometriosis (p < 0.05) compared with those with DIE or OMA. CONCLUSION: Endometriosis, particularly ovarian and deep infiltrating, significantly increases the risk of placenta previa, preterm birth, IUGR, and miscarriage. ART conception further amplifies these risks. While conflicting evidence exists for stillbirth and pre-eclampsia, lesion-specific trends suggest a need for individualized obstetric management. Larger studies are required to clarify these associations and optimize pregnancy care for affected women.
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Abstract

Background Endometriosis, affecting ~10% of women of reproductive age, is associated with infertility and adverse pregnancy outcomes. The condition is classified into superficial peritoneal endometriosis (SUP), ovarian endometriomas (OMA), and deep infiltrating endometriosis (DIE), with varying impacts on pregnancy. This review examines the relationship between lesion subtypes and adverse maternal–fetal outcomes.

Methods

A comprehensive literature search was conducted using PubMed, Scopus, Google Scholar, and Web of Science. Studies published between 2014 and 2025 that investigated pregnancy outcomes in women with endometriosis were included. Articles were screened based on predefined inclusion criteria, with 10 studies meeting the final selection. Outcomes analyzed included placenta previa, preterm birth, stillbirth, pre-eclampsia, intrauterine growth restriction (IUGR), and miscarriage.

Results

Women with endometriosis exhibited a significantly higher risk of placenta previa, particularly those with Stages III–IV disease (p < 0.05) and deep infiltrating lesions (p < 0.05). The risk was further elevated in pregnancies conceived via assisted reproductive technologies (ART) (p = 0.01). The likelihood of preterm birth was higher in patients with bladder DIE (p = 0.02) and rectal DIE (p = 0.01), but not in those with ovarian endometriomas. Meta-analysis data indicated a moderate association between endometriosis and pre-eclampsia (p < 0.05), particularly in patients with deep lesions (p = 0.03). Stillbirth risk showed inconsistent findings, with some studies reporting an increased risk (p < 0.05) while others found no significant association. IUGR and small-for-gestational-age (SGA) infants were more common in women with DIE (p = 0.03) and advanced-stage disease (p = 0.05). Miscarriage risk was elevated in patients with superficial endometriosis (p < 0.05) compared with those with DIE or OMA.

Conclusion

Endometriosis, particularly ovarian and deep infiltrating, significantly increases the risk of placenta previa, preterm birth, IUGR, and miscarriage. ART conception further amplifies these risks. While conflicting evidence exists for stillbirth and pre-eclampsia, lesion-specific trends suggest a need for individualized obstetric management. Larger studies are required to clarify these associations and optimize pregnancy care for affected women. CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to declare. DATA AVAILABILITY STATEMENT No data was generated during the development of this review.

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Condition tags

endometriosisdie_deep_infiltratinginfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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