The role of hormonal therapy in gynecological cancers-current status and future directions

Katrin Marie Sjoquist, Katrin M Sjoquist, Julie Martyn, Richard J. Edmondson, Michael Friedländer, Michael L Friedlander
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2011 · vol. 21(7) , pp. 1328–1333 · doi:10.1097/igc.0b013e31821d6021 · PMID:21720258 · W2037718360
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This review examines the current applications and future prospects of hormonal therapy in managing gynecological cancers.

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Abstract

Many gynecological cancers, including epithelial and stromal ovarian cancers; endometrial carcinomas; and some gynecological sarcomas, in particular endometrial stromal sarcomas, express estrogen and/ or progesterone receptors. Hormonal therapy, typically progestogens or tamoxifen, is commonly prescribed to patients with potentially hormone-sensitive recurrent or metastatic gynecological cancers with very variable response rates and clinical benefit reported. Aromatase inhibitors are now widely used to treat postmenopausal women with hormone receptor-positive breast cancers as they have greater activity than tamoxifen and are generally better tolerated. The role of aromatase inhibitors in gynecological cancers is uncertain and has not been well studied, although they do appear to be active. The current evidence to support the use of hormonal therapies including aromatase inhibitors in gynecological cancers is reviewed, and the gaps in our knowledge highlighted.

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MeSH descriptors

Aromatase Inhibitors Carcinoma Genital Neoplasms, Female Sarcoma Aromatase Inhibitors Carcinoma Female Genital Neoplasms, Female Granulosa Cell Tumor Granulosa Cell Tumor Hormone Replacement Therapy Humans Sarcoma

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