Should Sister Mary Joseph Nodule (SMJN) be Revisited?

Christina Pappa, Damato S, Hooman Soleymani majd
Clinical case reports · 2025 · doi:10.1002/ccr3.70705 · PMID:41200460 · PMC12586002
OA: gold
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This clinical image report presents a case of a Sister Mary Joseph nodule, which is a palpable umbilical metastasis typically associated with intra-abdominal malignancies such as gastric or pancreatic cancer. The authors review the literature to highlight the diagnostic significance of this physical exam finding and discuss its implications for patient prognosis and management. The paper emphasizes that identifying this nodule often indicates advanced disease requiring prompt oncologic evaluation. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Sister Mary Joseph's nodule represents a rare sign of advanced abdominal or pelvic malignancy, which indicates a poor prognosis for the patient. All clinicians should be aware of its significance and urgently refer the patient for further investigation and management.
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Author

Christina Pappa: data curation, investigation, project administration, resources, visualization, writing – original draft, writing – review and editing. Stephen Damato: investigation, resources, writing – review and editing. Hooman Soleymani Majd: conceptualization, methodology, project administration, resources, supervision, validation, visualization, writing – review and editing.

Conclusions

Written informed consent has been obtained for the publication of this clinical image.

Coi Statement

The authors declare no conflicts of interest.

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europepmc
last seen: 2026-09-13T09:25:22.628771+00:00