[Intraperitoneal and intrapleural two channel chemotherapy by cisplatinum (DDP) and sodium thiosulfate for the treatment of ovarian cancer]

We administrated cis-platinum 70-100 mg/m2 bolus, intraperitoneally or intrapleurally without diluting in saline, simultaneously combined with intravenous injection of sodium thiosulphate 1 gr/hr for 12 hours continuously or additional loading of sodium thiosulphate 4-6 g bolus on the initiation. The procedure does not require transfusion of specific hydration and keeps urine volume at a certain level, much less diuretics. For the treatment of 6 gynecological malignancies (2 primary ovarian carcinoma, 1 recurrent ovarian carcinoma, 1 pseudomyxoma peritonei, 1 clear cell carcinoma of cul de sac and 1 metastatic pleuritis carcinomatosa due to uterine cervical carcinoma) 12 courses treatments have been performed, without inducing nephrotoxicity except mild vomiting. All six cases are evaluable for efficacy according to Saito-Koyama criteria at this time: 4 CRs including 2 CRs for ascites and pleural effusion, 1 NC and 1 PD. This Two-Channel Chemotherapy (TCC) seems to be an important modality of chemotherapy for ovarian carcinoma in future.