Ability of ovarian steroids to regulate the expression of the fibroblast growth factor family in fibroblasts derived from uterine endometrium

Jiro Fujimoto, Masashi Hori, Satoshi Ichigo, Reiko Hirose, Teruhiko Tamaya
In: Journal of Biomedical Science · 1996 · vol. 3(4) , pp. 280–285 · doi:10.1007/bf02253708 · PMID:11725109 · W2018536431
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

Estradiol increased FGF-2 and its mRNA in uterine fibroblasts, while progesterone reduced this effect, suggesting steroid regulation of stromal FGF-2 in endometrial neovascularization.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study examined how ovarian steroid hormones regulate fibroblast growth factor (FGF) family gene expression in fibroblasts derived from human uterine endometrium, using RT-PCR/Southern blotting to measure FGF-1, FGF-2, and FGF-4 mRNA and ELISA to quantify FGF-2 protein. The authors found that estradiol significantly increased intracellular and secreted FGF-2 levels as well as FGF-family mRNA expression, while progesterone reduced the estradiol-induced increase. A key caveat is that the work uses endometrial-derived fibroblasts as a surrogate for stromal cells rather than studying intact tissue architecture and cell–cell interactions directly. Relevance to endometriosis: the paper focuses on endometrial (and stromal/fibroblast) regulation of angiogenic FGFs by sex steroids, which are mechanistically relevant to endometriosis-associated angiogenesis, though it does not explicitly study endometriosis or adenomyosis in this text.

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chemicals 4
estradiol progesterone estradiol sex hormone

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