Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility
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This trial found that gamete intrafallopian transfer (GIFT) yielded significantly higher pregnancy rates than intrauterine insemination (IUI) with or without ovarian hyperstimulation for unexplained infertility.
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Abstract
OBJECTIVE: To compare GIFT, intrauterine insemination (IUI) with, and without, ovarian hyperstimulation in the treatment of unexplained infertility. DESIGN: Women randomly allocated to one of three treatment protocols. SETTING: Northern Regional Fertility Centre. SUBJECTS: 59 couples with unexplained infertility of more than 3 years duration. INTERVENTIONS: Three cycles of either GIFT, IUI after ovarian hyperstimulation or IUI in a spontaneous cycle. MAIN OUTCOME MEASURES: Pregnancy resulting in a live birth. RESULTS: Fecundabilities were 0.12 after GIFT, 0.018 after ovarian hyperstimulation and IUI, and 0.018 after IUI in a spontaneous cycle. The fecundability after IUI was no different from that which would be expected without treatment in these couples but fecundability was significantly better (P greater than 0.02) after GIFT. CONCLUSIONS: This trial does not support the use of IUI in the treatment of unexplained infertility but confirms the value of GIFT.
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Cited by (4)
- Efficacy of treatment for unexplained infertility 1998
- Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: Should the guidelines be changed? 2003
- Unexplained infertility 2018
- A controlled study to assess the use of in vitro fertilization with donor semen after failed therapeutic donor insemination 1993
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Cited by (4)
- Unexplained infertility 2018
- Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: Should the guidelines be changed? 2003
- Efficacy of treatment for unexplained infertility 1998
- A controlled study to assess the use of in vitro fertilization with donor semen after failed therapeutic donor insemination 1993
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