Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis

Júlia Vallvé-Juanico, Suárez-Salvador E, Elena Suárez-Salvador, Josep Castellví, Agustín Ballesteros, Ballesteros A, A. Ballesteros, Hugh S. Taylor, Antonio Gil‐Moreno, Antonio Gil-Moreno, Xavier Santamaria, Xavier Santamaría
Fertility and sterility · 2017 · vol. 108(5) , pp. 858–867.e2 · doi:10.1016/j.fertnstert.2017.08.018 · PMID:28923287 · W2754844075
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This study investigates the aberrant expression of leucine-rich repeat containing G protein–coupled receptor 5 (LGR5)-positive cells in the eutopic endometrium and their implications in deep-infiltrating endometriosis.

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Abstract

ObjectiveTo characterize leucine-rich repeat containing G protein-coupled receptor 5-positive (LGR5+) cells from the endometrium of women with endometriosis.DesignProspective experimental study.SettingUniversity hospital/fertility clinic.Patient(s)Twenty-seven women with endometriosis who underwent surgery and 12 healthy egg donors, together comprising 39 endometrial samples.Intervention(s)Obtaining of uterine aspirates by using a Cornier Pipelle.Main outcomes measure(s)Immunofluorescence in formalin-fixed paraffin-embedded tissue from mice and healthy and pathologic human endometrium using antibodies against LGR5, E-cadherin, and cytokeratin, and epithelial and stromal LGR5+ cells isolated from healthy and pathologic human eutopic endometrium by fluorescence-activated cell sorting and transcriptomic characterization by RNA high sequencing.Result(s)Immunofluorescence showed that LGR5+ cells colocalized with epithelial markers in the stroma of the endometrium only in endometriotic patients. The results from RNA high sequencing of LGR5+ cells from epithelium and stroma did not show any statistically significant differences between them. The LGR5+ versus LGR5- cells in pathologic endometrium showed 394 differentially expressed genes. The LGR5+ cells in deep-infiltrating endometriosis expressed inflammatory markers not present in the other types of the disease.Conclusion(s)Our results revealed the presence of aberrantly located LGR5+ cells coexpressing epithelial markers in the stromal compartment of women with endometriosis. These cells have a statistically significantly different expression profile in deep-infiltrating endometriosis in comparison with other types of endometriosis, independent of the menstrual cycle phase. Further studies are needed to elucidate their role and influence in reproductive outcomes.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Receptors, G-Protein-Coupled Stromal Cells Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Fluorescent Antibody Technique Gene Expression Profiling Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Prospective Studies Receptors, G-Protein-Coupled

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