Computed Tomography–Based Radiation Therapy of Ovarian Remnants for Symptomatic Persistent Endometriosis

Haglund KE, Karl E Haglund, Karl Haglund, Akila N. Viswanathan, Viswanathan AN
Obstetrics and gynecology · 2008 · vol. 111(2) , pp. 579–583 · doi:10.1097/01.aog.0000299877.71874.91 · PMID:18239029 · W2060385935
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-24 ⓘ

Three women with symptomatic persistent endometriosis and ovarian remnants received computed tomography–based radiation therapy, inducing menopause and resolving their pain.

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This case report evaluates the use of computed tomography-based external beam radiation therapy to treat symptomatic persistent endometriosis in three patients with ovarian remnants who were not candidates for further surgery or medical management. The intervention successfully induced postmenopausal hormone levels within three months, resulting in the complete resolution of incapacitating pelvic pain for all subjects. The authors note that while effective, this approach requires careful patient selection due to potential long-term risks associated with radiation exposure. This paper is centrally about endometriosis — specifically, a novel radiation therapy approach for managing refractory pelvic pain caused by ovarian remnants.

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Abstract

BACKGROUND: Endometriosis, a major cause of pelvic pain in women, is driven by estrogen. Ovarian remnant irradiation may alleviate pelvic pain by eliminating estrogen production in appropriately selected women with endometriosis. CASE: Three patients with endometriosis causing incapacitating pelvic pain received 3D-imaging-based external beam radiation to doses of 1,500 to 2,100 cGy. All had pre-irradiation premenopausal follicle stimulating hormone levels and imaging evidence of ovarian remnants. None were candidates for further medical or surgical interventions. By 3 months after radiation, follicle stimulating hormone levels reached postmenopausal levels in all three patients, with complete resolution of the severe pelvic pain. CONCLUSION: Radiation therapy effectively induced menopause and relieved refractory pain from endometriosis. Careful selection of patients is necessary, given the potential for an increased long-term risk of radiation-related complications.
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Background

Endometriosis, a major cause of pelvic pain in women, is driven by estrogen. Ovarian remnant irradiation may alleviate pelvic pain by eliminating estrogen production in appropriately selected women with endometriosis. CASE: Three patients with endometriosis causing incapacitating pelvic pain received 3D-imaging–based external beam radiation to doses of 1,500 to 2,100 cGy. All had pre-irradiation premenopausal follicle stimulating hormone levels and imaging evidence of ovarian remnants. None were candidates for further medical or surgical interventions. By 3 months after radiation, follicle stimulating hormone levels reached postmenopausal levels in all three patients, with complete resolution of the severe pelvic pain.

Conclusion

Radiation therapy effectively induced menopause and relieved refractory pain from endometriosis. Careful selection of patients is necessary, given the potential for an increased long-term risk of radiation-related complications.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Radiotherapy, Computer-Assisted Adult Endometriosis Endometriosis Female Humans Ovarian Diseases Ovarian Diseases Tomography, X-Ray Computed

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Cited by (5)

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