Efficacy of guided ovarian hyperstimulation in patients with mild type endometriosis

Emilija Jasović-Siveska, Emilija Jašović-Siveska, Jasović-Siveska E, Jasović V, Vladimir Jasović
Vojnosanitetski pregled · 2008 · vol. 65(2) , pp. 147–152 · doi:10.2298/vsp0802147j · PMID:18365672 · W2005688551
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Human menopausal gonadotropin stimulation and human chorionic gonadotropin induction are effective for treating infertility, particularly in patients with mild endometriosis.

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This study evaluated the efficacy of human menopausal gonadotrophin stimulation and chorionic gonadotrophin induction in treating infertility among patients with mild endometriosis compared to those with unexplained infertility. The researchers analyzed data from fifty women diagnosed with mild endometriosis via laparoscopy and fifty women with unknown etiology for their infertility, administering identical therapeutic protocols to both groups. Results indicated that ovulation occurred in 74% to 77.78% of the endometriosis group across three cycles, while the unexplained infertility group achieved higher rates ranging from 82% to 85.71%. The authors concluded that this stimulation protocol is an efficient treatment for infertility, specifically noting its effectiveness in cases involving mild endometriosis. This paper is centrally about endometriosis — specifically assessing the response of mild type endometriosis patients to guided ovarian hyperstimulation for infertility.

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Abstract

BACKGROUND/AIM: Endometriosis befalls in one of the most frequent gynecologic diseases. It manifests itself by the presence and growth of focus of endometrium out of the uterus cavum that reacts to hormonal stimulations as the normal uterus endometrium does. Hyperstimulation and induction of ovulation together with intrauterine insemination (IUI) are the most frequently used treatments of unexplained infertility in patients with mild type endometriosis. The aim of this study was to compare the effects of stimulation using human meno pausal gonadotrophine (hMG) in the patients with mild type endometriosis to the patients with infertility of unknown ethiology. METHODS: The study included 50 patients with unexplained infertility (group N), as well as 50 patients with mild type endometriosis (group E) confirmed by laparoscopy. Within the same therapeutic protocole hIMG stimulation and horionic gonadotrophine induction (hCG) were used. RESULTS: In the group E ovulation occurred in 74% of the pa tients during the first stimulation, in 77.78% during the second cycle, and in 75% of the patients during the third one. Regarding the group N, ovulation appeared in 82% of the patients during the first stimulation. Stimulation was performed two times more in 38 patients with unknown couse of infertil ity, and ovulation appeared in 84.21 percent of them. In the group N stimulation was performed three times in 28 women resulting in ovulation in 85.71% of them. CONCLUSION: Con sidering the obtained results it can be concluded that hMG stimulation and hCG induction are efficient in the treatment of infertility, particularly in mild type endometriosis.
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Vojnosanitetski pregled 2008 Volume 65, Issue 2, Pages: 147-152 Efficacy of guided ovarian hyperstimulation in patients with mild type endometriosis Jašović-Siveska Emilija (Univerzitet Sveti Kliment Ohridski, Visoka medicinska škola, Bitola, Makedonija) Background/Aim. Endometriosis befalls in one of the most frequent gynecologic diseases. It manifests itself by the presence and growth of focus of endometrium out of the uterus cavum that reacts to hormonal stimulations as the normal uterus endometrium does. Hyperstimulation and induction of ovulation together with intrauterine insemination (IUI) are the most frequently used treatments of unexplained infertility in patients with mild type endometriosis. The aim of this study was to compare the effects of stimulation using human menopausal gonadotrophine (hMG) in the patients with mild type endometriosis to the patients with infertility of unknown ethiology. Methods. The study included 50 patients with unexplained infertility (group N), as well as 50 patients with mild type endometriosis (group E) confirmed by laparoscopy. Within the same therapeutic protocole hMG stimulation and horionic gonadotrophine induction (hCG) were used. Results. In the group E ovulation occurred in 74% of the patients during the first stimulation, in 77.78% during the second cycle, and in 75% of the patients during the third one. Regarding the group N, ovulation appeared in 82% of the patients during the first stimulation. Stimulation was performed two times more in 38 patients with unknown couse of infertility, and ovulation appeared in 84.21% of them. In the group N stimulation was performed three times in 28 women resulting in ovulation in 85.71% of them. Conclusion. Considering the obtained results it can be concluded that hMG stimulation and hCG induction are efficient in the treatment of infertility, particularly in mild type endometriosis. Keywords: endometriosis, infertility, gonadotropins, insemination, artificial, ovulation, pregnancy https://doi.org/10.2298/VSP0802147J Full text ( 459 KB) Jašović Vladimir (Ginekološko-akušerska klinika Narodni Front, Beograd)

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Condition tags

endometriosisinfertility

MeSH descriptors

Chorionic Gonadotropin Endometriosis Infertility, Female Menotropins Ovulation Induction Adult Chorionic Gonadotropin Endometriosis Female Humans Infertility, Female Infertility, Female Menotropins Menotropins Pregnancy

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References (11)

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