Therapeutic vectors of treatment of ovarian endometriomas

О. С. Шаповал
In: HEALTH OF WOMAN · 2018 · pp. 83–86 · doi:10.15574/hw.2018.130.83 · W3146595977
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This study evaluated complex therapy for ovarian endometriomas, finding that treatment with immunomodulators, indole-3-carbinol, and gestagen-containing contraceptives yielded high recovery rates and low relapse in women of reproductive age.

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This study evaluated clinical and immunological features in 32 women aged 18 to 49 with ovarian endometriomas compared to 50 healthy controls. Researchers identified immune system insufficiency in the patient group and observed that surgical intervention was required in over 74% of cases. Postoperative management included a complex therapy regimen utilizing immunomodulators, indole-3-carbinol, and gestagen-containing oral contraceptives. The authors concluded that this combined approach yielded high recovery rates and low relapse frequencies among reproductive-age patients. This paper is centrally about endometriosis — specifically focusing on the diagnosis and therapeutic management of ovarian endometriomas.

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Abstract

The objective: to study clinical and anamnesis features in patients with ovarian endometriomas and to improve existing algorithms of treatment women with ovarian endpmetriomas. Materials and methods. The study included 32 patients aged 18 – 49 years with ovarian endometriomas and 50 healthy women. A general clinical, sonographic, immunological examination was conducted. Results. The analysis of the study data revealed the I degree of insufficiency of the adaptive link and the I–II degree of insufficiency of the nonspecific link of the immune system. In 74.51% of cases surgical treatment of the pathological process was carried out. As a conservative therapy and in the postoperative period the patients received complex therapy with immunomodulators, drugs of indole-3-carbinol, combined oral contraceptives with gestagen. Conclusion. The application of our proposed complex therapy of ovarian endometriomas in women of reproductive age showed a high recovery rate and a low relapse rate. Key words: ovarian endometrioma, reproductive age, immune dysfunction, treatment.
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Materials

and methods. The study included 32 patients aged 18 – 49 years with ovarian endometriomas and 50 healthy women. A general clinical, sonographic, immunological examination was conducted. Results. The analysis of the study data revealed the I degree of insufficiency of the adaptive link and the I–II degree of insufficiency of the nonspecific link of the immune system. In 74.51% of cases surgical treatment of the pathological process was carried out. As a conservative therapy and in the postoperative period the patients received complex therapy with immunomodulators, drugs of indole-3-carbinol, combined oral contraceptives with gestagen. Conclusion. The application of our proposed complex therapy of ovarian endometriomas in women of reproductive age showed a high recovery rate and a low relapse rate. Key words: ovarian endometrioma, reproductive age, immune dysfunction, treatment.

References

1. Adamovskaya TN. 2013. Osobennosti vedeniya patsientok s endometrioz-assotsiirovannyim besplodiem. Zdorove zhenschiny 3(79):187–191. 2. Asien P, Velasko I. 2014. Endometrioz: khvoroba, yaka zalyshaietsia zahadkoiu. Zdorovia Ukrainy 1:52–55. 3. Gasparyan SA, Ionova RM, Popova OS. 2015. Endometrioz i fertilnost. Klyuchevyie momentyi lecheniya. Akusherstvo, ginekologiya, reproduktsiya 4:66–72. 4. Guseynova OM. 2011. Osobennosti immunnogo otveta u zhenschin s genitalnyim endometriozom. Sarat. n.-med. zh. 4:804–808. 5. Unanyan AL. 2010. Endometrioz i reproduktivnoe zdorove zhenschin. Akusherstvo, ginekologiya, reproduktsiya 3(4):6–11. 6. Burney RO. 2013. The genetics and biochemistry of endometriosis. Curr. Opin. Obstet. Gynecol. 25:280–286. https://doi.org/10.1097/GCO.0b013e3283630d56; PMid:23759832 7. Harada T. 2014. Endometriosis: Pathogenesis and Treatment. Japan. Springer.: 475. PMid:25193821 8. Szamatowicz M. 2007. Endometriosis – is the best way of infertility treatment? IFFS. – Abstract Book. – FC 1505: 80.

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