Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study

Helene Vistisen Ryde, H. Ryde, M Reinert, Marie S Reinert, Dorthe Hartwell, C. K. Ekelund, Lars Køber, Emil Loldrup Fosbøl, Eva Havers‐Borgersen
European heart journal · 2026 · doi:10.1093/eurheartj/ehag615 · PMID:42568051 · W7201980103
article OA: closed public-domain-us
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-11 ⓘ

This Danish nationwide cohort study found that women with endometriosis had a 52% increased long-term risk of venous thromboembolism compared to matched controls, even after adjustments.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND AND AIMS: Endometriosis affects ∼10% of women of reproductive age. Emerging evidence suggests a link between endometriosis and systemic inflammation, potentially increasing the risk of venous thromboembolism (VTE), yet data on the association between endometriosis and VTE are lacking. The aim was to examine the association between endometriosis and long-term risk of VTE. METHODS: A nationwide, registry-based cohort study including all women with endometriosis from 1977 to 2024, matched 1:4 on birth and index year with women from the background population without endometriosis. The primary outcome was VTE as a composite of deep venous thrombosis and pulmonary embolism, while the individual components comprised the secondary outcomes. RESULTS: The study included 63 999 women with endometriosis and 255 996 matched female controls. At baseline, women with endometriosis had a higher burden of comorbidities, had greater use of medications, and more often had a history of abdominal/gynaecological surgeries. The incidence rate of VTE was higher in women with endometriosis [2.18 per 1000 person-years; 95% confidence interval (CI) 2.10-2.26] compared with controls (1.54 per 1000 person-years; 95% CI 1.51-1.58). In Cox regression analyses, endometriosis was associated with a significantly increased risk of VTE, even after adjustment for relevant comorbidities and use of hormonal contraception [unadjusted hazard ratio (HR) 1.43; 95% CI 1.36-1.50 and adjusted HR 1.52; 95% CI 1.42-1.63]. Similar results were observed for VTE subgroups: deep venous thrombosis alone (adjusted HR 1.50; 95% CI 1.38-1.63) and pulmonary embolism alone (adjusted HR 1.52; 95% CI 1.36-1.70). CONCLUSIONS: Endometriosis was associated with an increased long-term risk of VTE compared with a matched background population. These findings highlight the importance of clinical awareness and consideration of thrombotic risk in women with a history of endometriosis.

My notes (saved in your browser only)

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Source provenance

europepmc
last seen: 2026-09-28T06:13:43.407401+00:00
openalex
last seen: 2026-09-28T06:04:30.917539+00:00
pubmed
last seen: 2026-09-28T06:06:33.458722+00:00
unpaywall
last seen: 2026-09-28T06:20:55.906821+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine