Reproductive outcome after laparoscopy for stage I and stage II endometriosis

In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2022 · vol. 11(6) , pp. 1740 · doi:10.18203/2320-1770.ijrcog20221450 · W4281681410
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-18 ⓘ

Laparoscopic excision of stage I and II endometriosis in 82 women resulted in a 41.5% pregnancy rate, with conception occurring spontaneously within 6 months, particularly in cases with tubo-ovarian relationship improvement.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-18 · read from full text ⓘ

This prospective observational study (July 2020–June 2021) at a single hospital followed 82 women with stage I (minimal) or stage II (mild) endometriosis diagnosed at laparoscopy, with lesions excised completely, documenting time to conception, mode of conception, and changes in endometriosis pain over 6 months. Overall, 41.5% achieved successful pregnancy, with conception rates of 38.2% in stage I and 61.8% in stage II; 82.4% conceived spontaneously, most within 3–6 months, and 58.5% underwent treatment for periadnexial adhesions (with 41.2% conceiving in that subgroup). The paper reports that pain improved and that younger age, optimal BMI, and good AMH level were favorable factors, while the main caveat is limited follow-up to 6 months and the lack of a randomized comparison group. This paper is centrally about endometriosis — reproductive outcome after laparoscopy for stage I and stage II endometriosis.

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Abstract

Background: Endometriosis is a chronic and recurrent disease commonly afflicting women of reproductive age, contributing to 30-50% cases of infertility. 30% cumulative probability of achieving pregnancy is reported following surgical management of minimal and mild endometriosis.Methods: Prospective observational study was conducted at Apollo Women’s hospital, Chennai between July 2020 and June 2021. 82 eligible women who satisfied the study criteria took part in it. During surgery, diagnosis of Stage I (Minimal endometriosis, few superficial implants, score 1-5) or Stage II endometriosis (Mild endometriosis, more deeper implants, score 6-15) made and lesions excised completely. Patients followed up for 6 months for outcome. Time taken, mode of conception and improvement in pain score were documented. Collected data was analysed.Results: 41.5% had successful pregnancy outcome, which is higher than that reported in literature. 43.9% had stage I endometriosis of which 38.2% conceived and 56.1% had stage II endometriosis of which 61.8% conceived. 82.4% conceived spontaneously, 32.4% within 3 months and 67.6% in 3-6 months with mean duration of 4 months. 58.5% women were treated for periadnexial adhesions altering tubo-ovarian relationship, of which 41.2% women conceived which is statistically significant.Conclusions: Large proportion of women undergoing laparoscopy surgical management of stage I and stage II endometriosis in successfully achieved a conception, spontaneously and within a short span after surgery. Pain due to endometriosis was also relieved. Favourable factors to achieve pregnancy were younger age, optimal BMI and good AMH level. Laparoscopy is an attractive and effective option for women with minimal or mild endometriosis with infertility.
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Background

Endometriosis is a chronic and recurrent disease commonly afflicting women of reproductive age, contributing to 30-50% cases of infertility. 30% cumulative probability of achieving pregnancy is reported following surgical management of minimal and mild endometriosis.

Methods

Prospective observational study was conducted at Apollo Women’s hospital, Chennai between July 2020 and June 2021. 82 eligible women who satisfied the study criteria took part in it. During surgery, diagnosis of Stage I (Minimal endometriosis, few superficial implants, score 1-5) or Stage II endometriosis (Mild endometriosis, more deeper implants, score 6-15) made and lesions excised completely. Patients followed up for 6 months for outcome. Time taken, mode of conception and improvement in pain score were documented. Collected data was analysed.

Results

41.5% had successful pregnancy outcome, which is higher than that reported in literature. 43.9% had stage I endometriosis of which 38.2% conceived and 56.1% had stage II endometriosis of which 61.8% conceived. 82.4% conceived spontaneously, 32.4% within 3 months and 67.6% in 3-6 months with mean duration of 4 months. 58.5% women were treated for periadnexial adhesions altering tubo-ovarian relationship, of which 41.2% women conceived which is statistically significant.

Conclusions

Large proportion of women undergoing laparoscopy surgical management of stage I and stage II endometriosis in successfully achieved a conception, spontaneously and within a short span after surgery. Pain due to endometriosis was also relieved. Favourable factors to achieve pregnancy were younger age, optimal BMI and good AMH level. Laparoscopy is an attractive and effective option for women with minimal or mild endometriosis with infertility. Metrics

References

Berek JS. Berek and Novak’s Gynecology. 14th ed. Philadelphia, PA: Lippincott Williams and Wilkins. 2006. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-49. Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, diagnosis and clinical management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. American Society for Reproductive. Revised American Society for Reproductive Medicine classification of endometriosis. Fertil Steril. 1997;67(5):817-21. Dunselman GAJ, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400-12. Marcoux S, Maheux R, Bérubé S. Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med. 1997;337(4):217-22. National Health Portal of India, gateway to Authentic health information. Gov.in. Available at: https://www.nhp.gov.in/disease/reproductive-system/infertility. Accessed on 9 June 2021. Parazzini F. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod. 1999;14(5):1332-4. Moini A, Bahar L, Ashrafinia M, Eslami B, Hosseini R, Ashrafinia N. Fertility outcome after operative laparoscopy versus no treatment in infertile women with minimal or mild endometriosis. Int J Fertil Steril. 2012;5(4):235-40. Porpora MG, Pultrone DC, Bellavia M, Franco C, Crobu M, Cosmi EV. Reproductive outcome after laparoscopic treatment of endometriosis. Clin Exp Obstet Gynecol. 2002;29(4):271-3. Nowroozi K, Chase JS, Check JH, Wu CH. The importance of laparoscopic coagulation of mild endometriosis in infertile women. Int J Fertil. 1987;32(6):442-4. Parazzini F. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod. 1999;14(5):1332-4. Zeng C, Xu J-N, Zhou Y, Zhou YF, Zhu SN, Xue Q. Reproductive performance after surgery for endometriosis: predictive value of the revised American Fertility Society classification and the endometriosis fertility index. Gynecol Obstet Invest. 2014;77(3):180-5. Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98(3):591-8. Opøien HK, Fedorcsak P, Byholm T, Tanbo T. Complete surgical removal of minimal and mild endometriosis improves outcome of subsequent IVF/ICSI treatment. Reprod Biomed Online. 2011;23(3):389-95. Fuchs F, Raynal P, Salama S, Guillot E, Le Tohic A, Chis C, et al. Fertilité après chirurgie cœlioscopique de l’endométriose pelvienne chez des patientes en échec de grossesse. J Gynecol Obstet Biol Reprod (Paris). 2007;36(4):354-9. FIGO. Endometrosis, 2020. Available at: https://www.figo.org/sites/ default/files/2020-07/Endometriosis%20Slides% 202016%20-%20Rep%20Med.pdf. Accessed on 9 June 2021.

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