Ovarian cancer: etiology, risk factors, and epidemiology

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Abstract

Little is known regarding the early aspects of ovarian carcinogenesis. As a consequence, the identification of women at risk for the disease is based primarily on clinical grounds, with family history being the most important risk factor. In this review, we will discuss the various hypotheses regarding ovarian etiology and pathogenesis. In addition, we will discuss the epidemiology of ovarian cancer, including hereditary, reproductive, hormonal, inflammatory, dietary, surgical, and geographic factors that influence ovarian cancer risk.

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Condition tags

endometriosis

MeSH descriptors

Ovarian Neoplasms Ovarian Neoplasms Androgens Androgens Breast Feeding Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Diet Endometriosis Endometriosis Epithelium Epithelium Estrogens Estrogens Exercise Female Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Geography

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europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
pubmed
last seen: 2026-05-13T22:16:23.388809+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine