Ruptured uterine pyomyoma with multiorgan dysfunction syndrome

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This case report details the successful management of a woman who presented with a ruptured uterine pyomyoma leading to septic shock, multiorgan dysfunction syndrome, and subsequent recovery following hysterectomy and antibiotic treatment.

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This paper reports a case of a woman with chronic hypertension and a recent myomectomy who presented with fever, vomiting, diarrhea, abdominal pain, septic shock, acute kidney injury, and respiratory failure. Imaging identified a large necrotic fibroid with hydrosalpinx, ascites, and pleural effusion, and blood cultures grew Escherichia coli; she underwent emergency surgery including total abdominal hysterectomy and bilateral salpingo-oophorectomy, with intraoperative purulence and E. coli confirmed from purulent material, followed by intensive care and gradual recovery. Pathology showed leiomyomata with degenerative changes, benign endometrial polyps, and endometriosis. As a single case report, it does not provide generalizable evidence, and the paper concludes with successful resolution without recurrence on follow-up. This paper is centrally about endometriosis — pathology in the ruptured uterine pyomyoma case identifies endometriosis alongside other gynecologic findings.

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Abstract

A woman with a history of chronic hypertension, no previous pregnancies and a recent myomectomy presented to the emergency department with fever, vomiting, diarrhoea and abdominal pain. She showed signs of septic shock, acute kidney injury and respiratory failure. Imaging revealed a large necrotic fibroid, hydrosalpinx, ascites and pleural effusion. Blood cultures showed Escherichia coli growth. She underwent emergency surgery for total abdominal hysterectomy, bilateral salpingoophorectomy and hysteroscopy. Intraoperatively, purulent discharge was found, and cultures confirmed E. coli infection. Pathology revealed leiomyomata with degenerative changes, benign endometrial polyps and endometriosis. Postoperatively, she received intensive care and showed gradual improvement, eventually being discharged in a stable condition. Follow-up appointments showed resolution of symptoms, wound healing and no infection recurrence. Antibiotics were discontinued, and the pleural drain was removed. Overall, the patient had a successful recovery with no complications noted during follow-up.
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Article Text Abstract A woman with a history of chronic hypertension, no previous pregnancies and a recent myomectomy presented to the emergency department with fever, vomiting, diarrhoea and abdominal pain. She showed signs of septic shock, acute kidney injury and respiratory failure. Imaging revealed a large necrotic fibroid, hydrosalpinx, ascites and pleural effusion. Blood cultures showed Escherichia coli growth. She underwent emergency surgery for total abdominal hysterectomy, bilateral salpingoophorectomy and hysteroscopy. Intraoperatively, purulent discharge was found, and cultures confirmed E. coli infection. Pathology revealed leiomyomata with degenerative changes, benign endometrial polyps and endometriosis. Postoperatively, she received intensive care and showed gradual improvement, eventually being discharged in a stable condition. Follow-up appointments showed resolution of symptoms, wound healing and no infection recurrence. Antibiotics were discontinued, and the pleural drain was removed. Overall, the patient had a successful recovery with no complications noted during follow-up. - Infections - Obstetrics, gynaecology and fertility Statistics from Altmetric.com Footnotes Contributors FA: Conceptualisation, investigation, writing – original draft, writing – review and editing and visualisation. DS: Conceptualisation, literature review, review and editing, and supervision. She is the guarantor. RSK: Conceptualisation, review and supervision. TK: Literature review and visualisation. Each author has approved the final version of the manuscript and agrees to be accountable for all aspects of the work. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy. Competing interests None declared. Provenance and peer review Not commissioned; externally peer reviewed.

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Condition tags

endometriosis

MeSH descriptors

Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections Escherichia coli Infections

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Source provenance

europepmc
last seen: 2026-09-07T06:12:11.729357+00:00
pubmed
last seen: 2026-09-07T06:08:25.512024+00:00
unpaywall
last seen: 2026-05-11T08:34:28.763810+00:00
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