Polyzystisches Ovarialsyndrom und Endometriose – Konventionelle Therapien

In: Praxis der Integrativen Medizin · 2026 · pp. 373–384 · doi:10.1007/978-3-662-68171-8_27 · W7124149187
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This paper describes polycystic ovary syndrome as a combination of endocrine and metabolic disorders often presenting with anovulatory cycles, androgenization, and obesity, and endometriosis as a chronic, inflammatory, hormone-dependent disease characterized by endometrial tissue outside the uterus.

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The paper describes PCOS as an endocrine-metabolic disorder characterized by features such as anovulatory cycles, menstrual irregularities, androgenization, and increased rates of obesity, diabetes mellitus risk, hypertension, and metabolic syndrome; it also notes common psychological comorbidities and that persistent anovulation may increase endometrial cancer risk. It further characterizes endometriosis as a chronic inflammatory hormone-dependent disease defined by endometrium-like tissue outside the uterine cavity, with clinical consequences that can persist beyond reproductive years into postmenopause. The major limitation is that this text functions as a narrative/educational overview and does not present original experimental data or a specific study design. Relevance to endometriosis: endometriosis is explicitly discussed in the same chapter alongside PCOS as a chronic hormone-dependent condition with long-lasting consequences, though the paper’s main focus is the general description of PCOS and conventional context about endometriosis rather than shared mechanisms or treatments.

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Zusammenfassung Das polyzystische Ovarialsyndrom stellt eine Kombination aus endokrinen und metabolischen Störungen dar. Der Name leitet sich von der sonografisch darstellbaren veränderten Morphologie der Ovarien ab. Betroffene Frauen weisen häufig anovulatorische Zyklen, Zyklusstörungen und Zeichen einer Androgenisierung auf. Sie sind gehäuft adipös mit einem erhöhten Risiko für Diabetes mellitus, Hypertonie und die Ausbildung eines metabolischen Syndroms. Psychische Veränderungen wie Depressionen, Angst- und Schlafstörungen treten regelmäßig auf. Durch persistierende Anovulation kann das Risiko eines Endometriumkarzinoms erhöht sein. Ein PCOS manifestiert sich häufig schon in der Adoleszenz. Endometriose ist eine chronische, entzündliche, hormonabhängige Erkrankung und definiert sich durch das Vorhandensein von endometriumartiger Schleimhaut außerhalb des Cavum uteri. Obwohl sie sich meist in der reproduktiven Phase bemerkbar macht, können die klinischen Folgen bis weit in die Postmenopause andauern. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Literatur Becker CM, Bokor, Heikinheimo O et al; ESHRE Endometriosis Guideline Group (2022) ESHRE guideline: endometriosis. Hum Reprod Open 2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009 Burla L, Scheiner D, Samartzis EP et al (2019) The ENZIAN score as a preoperative MRI-based classification instrument for deep infiltrating endometriosis. Arch Gynecol Obstet 300(1):109–116 Burla L, Kalaitzopoulos DR, Metzler JM et al (2021) Popularity of endocrine endometriosis drugs and limited alternatives in the present and foreseeable future: a survey among 1420 affected women. Eur J Obstet Gynecol Reprod Biol 262:232–238 Chapron C, Marcellin L, Borghese B, Santulli P (2019) Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol 15:666–682 Guerriero S, Condous G, van den Bosch T et al (2016) Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound Obstet Gynecol 48(3):318–332 Hoeger KM, Dokras A, Piltonen T (2021) Update on PCOS: consequences, challenges, and guiding treatment. J Clin Endocrinol Metab 106(3):e1071–e1083 Joham AE, Teede HJ (2022) PCOS – a metabolic condition with health impacts on women and men. Nat Rev Endocrinol 18(4):197–198. https://doi.org/10.1038/s41574-022-00636-z Keckstein J, Saridogan E, Ulrich UA et al (2021) The Enzian classification: a comprehensive non-invasive and surgical description system for endometriosis. Acta Obstet Gynecol Scand 100(7):1165–1175 McCartney CR, Marshall JC (2016) Clinical practice. Polycystic ovary syndrome. N Engl J Med 375(1):54–64 Muraoka A, Suzuki M, Hamaguchi T et al (2023) Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Sci Transl Med 15(700):eadd1531. https://doi.org/10.1126/scitranslmed.add1531 Rahmioglu N, Mortlock S, Ghiasi M et al (2023) The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 55(3):423–436. https://doi.org/10.1038/s41588-023-01323-z Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19(1):41–47. https://doi.org/10.1093/humrep/deh098 Stener-Victorin E, Teede H, Norman RJ et al (2024) Polycystic ovary syndrome. Nat Rev Dis Primers 10(1):27. https://doi.org/10.1038/s41572-024-00511-3 Teede HJ, Tay CT, Laven J et al (2023) Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod 38(9):1655–1679. https://doi.org/10.1093/humrep/dead156 Thurnherr N, Burla L, Metzler JM et al (2024) Attitudes and perceptions of affected women towards endocrine endometriosis therapy: an international survey based on free-word association networks. Hum Reprod 39(1):83–92. https://doi.org/10.1093/humrep/dead221 Zondervan KT, Becker CM, Missmer SA (2020) Endometriosis. N Engl J Med 382(13):1244–1256 Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2026 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature About this chapter Cite this chapter Imesch, P. (2026). Polyzystisches Ovarialsyndrom und Endometriose – Konventionelle Therapien. In: Langhorst, J., Krenner, L. (eds) Praxis der Integrativen Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-68171-8_27 Download citation DOI: https://doi.org/10.1007/978-3-662-68171-8_27 Published: Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-662-68170-1 Online ISBN: 978-3-662-68171-8 eBook Packages: Medicine (German Language)

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