Reproductive Outcomes in Infertile Women with Endometriosis Undergoing Assisted Reproductive Technology

Can Benlioglu, Can Benlioğlu, Telek SB, Savci Bekir Telek, Savcı Bekir Telek, Ata B, Barış Ata, Baris Ata
Gynecologic and obstetric investigation · 2025 · vol. 90(4) , pp. 374–380 · doi:10.1159/000543213 · PMID:39864416 · W4406864226
Review OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Endometriosis presence, even with ovarian reserve compromise, did not significantly affect oocyte quality, embryo development, or ART success rates compared to other infertility diagnoses.

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Abstract

BACKGROUND: Endometriosis-related infertility and its treatment with assisted reproductive technologies (ART) have been broadly researched. Yet, underlying mechanisms of infertility, particularly in the absence of tubal dysfunction, remain unclear. While the impact of inflammatory milieu on the ovary and/or endometrium has been indicated as a contributing factor, recent evidence from euploid transfers and donor cycles questions the extent of these effects. Moreover, the frequent coexistence of other confounders, such as adenomyosis, further complicates the clinical picture, making it difficult to isolate the specific impact of endometriosis on ART outcomes. OBJECTIVES: The aim of the study was to evaluate the influence of endometriosis on various aspects of ART, including oocyte competence, ART success, and whether surgical or medical treatments improve these. METHODS: We primarily focused on recent high-quality sources, including systematic reviews, large-scale observational studies, and meta-analyses, to provide a robust and reliable synthesis of the available evidence. OUTCOME: While oocyte yield can decrease in the presence of an endometrioma or history of endometrioma excision, oocyte quality, early embryo development indicators, aneuploidy rates, and clinical outcomes of endometriosis patients do not differ from other infertility diagnoses in ART setting. Surgical treatments and hormonal suppression before ART do not seem to improve outcomes. Ovarian stimulation for ART does not exacerbate endometriosis symptoms. CONCLUSIONS AND OUTLOOK: Endometriosis, despite its high prevalence among infertile patients, does not inherently impair ART success, except in cases where ovarian reserve is compromised due to ovarian disease or its surgical treatment. The causal link between endometriosis and infertility remains an enigma, and future studies should continue to explore this association with other confounding factors.

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Condition tags

endometriosisadenomyosisendometriomainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (46)

Cited by (2)

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