Recurrent Cerebral Infarcts Associated with Uterine Adenomyosis: Successful Prevention by Surgical Removal

Manato Yasuda, Yoshitaka Yamanaka, Hiroki Kano, Nobuyuki Araki, Hiroshi Ishikawa, Jun-Ichiro Ikeda, Jun‐ichiro Ikeda, Satoshi Kuwabara
Internal medicine (Tokyo, Japan) · 2021 · vol. 61(5) , pp. 735–738 · doi:10.2169/internalmedicine.7320-21 · PMID:34483206 · PMC8943379 · W3196926315
article OA: gold CC0 ⤵ 10 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

A woman with uterine adenomyosis experienced recurrent cerebral infarcts until hysterectomy and bilateral salpingo-oophorectomy successfully prevented further thrombosis for five years.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper reports a 47-year-old Japanese woman with uterine adenomyosis who developed recurrent cerebral infarcts during menstruation, suggesting a thrombosis mechanism considered analogous to Trousseau’s syndrome despite adenomyosis being a benign gynecological condition. The authors initially used edoxaban for thrombosis prevention, but recurrence occurred, indicating that anticoagulation was not effective in preventing further infarcts in this case. After hysterectomy and bilateral salpingo-oophorectomy, the patient experienced no recurrence of cerebral infarcts for five years without antiplatelet or anticoagulant agents, with the major limitation being that the evidence is limited to a single case report. This paper is centrally about adenomyosis — it describes recurrent cerebral infarcts temporally associated with menstruation in a patient with uterine adenomyosis and prevention after surgical removal.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Hypercoagulability associated with malignant tumors causes thrombosis, termed Trousseau's syndrome, but is rarely associated with benign gynecological tumors, such as myoma and adenomyosis. We herein report a 47-year-old Japanese woman with uterine adenomyosis who developed multiple cerebral infarcts during menstruation. Edoxaban was initially used for prevention but failed to prevent recurrence of thrombosis. However, hysterectomy and bilateral salpingo-oophorectomy resulted in the successful prevention of recurrence of cerebral infarct for five years without antiplatelet or anticoagulant agents. In our patient, the surgical removal of adenomyosis was highly effective for preventing thrombosis in a patient with adenomyosis.

My notes (saved in your browser only)

Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Thrombophilia Anticoagulants Cerebral Infarction Cerebral Infarction Cerebral Infarction Female Humans Hysterectomy Hysterectomy Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (10)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:20.309598+00:00
License: CC0 · commercial use OK