Decipher The Role of The Epigenetic Regulators in Progression of Women with Endometriosis - Associated Infertility

Ashish Ashish, Sangeeta Rai, Shivani Misra, Kusum Kusum, Arunim Shah, Chandra Prakash Chaturvedi, Royana Singh
In: JOURNAL OF SCIENTIFIC RESEARCH · 2022 · vol. 66(01) , pp. 232–237 · doi:10.37398/jsr.2022.660125 · W4214557910
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the differential expression of HOX genes and DNA methyltransferases in women with endometriosis-associated infertility to understand their roles in disease progression.

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Abstract

There is continuous increase of inflammatory disease conditions in individuals and it also include a disease called endometriosis. In endometriosis disease, endometrial tissues are present outside the intra-uterine locations having inflammatory properties. HOX genes, are developmental genes, code for proteins and work as critical key regulatory factor during embryogenesis, while epigenetic events regulate gene transcriptions, without changing the underlying DNA sequences, and that includes DNA methyltransferases (DNMTs). Here in this experimental study, the differential expression of HOXA1, HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11, HOXB6, MLL2, DNMT1, DNMT3A, DNMT3B, PRDM16, G9A and VENTX genes were done. The comparative expression studies of these genes with control, will decipher the role of these genes in diseases progression and further correlating these genes together the molecular pathways can be sketched out.

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endometriosisinfertility

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