Placental-type alkaline phosphatase in peritoneal fluid of women with endometriosis

Kang JO, Jae O. Kang, J O Kang, W A Hudak, Wayne A. Hudak, Hudak WA, W J Crowley, Crowley WJ, William Crowley, B S Criswell, Criswell BS
Clinica chimica acta; international journal of clinical chemistry · 1990 · vol. 186(2) , pp. 285–294 · doi:10.1016/0009-8981(90)90046-u · PMID:2311256 · W2026954240
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This study investigated placental-type alkaline phosphatase (PLAP) levels in peritoneal fluid from women with endometriosis and found it to be a potential biomarker for the condition.

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Abstract

Alkaline phosphatase (ALP) activities were studied in peritoneal fluid obtained from patients with untreated endometriosis and control women who had normal pelves. The patients (n = 18) had significantly higher total ALP (8.65 +/- 5.69 mU/mg, p less than 0.01) and thermostable ALP (0.28 +/- 0.23 mU/mg, p less than 0.05) than the controls (n = 7) (total ALP = 2.41 +/- 1.15; thermostable ALP = 0.09 +/- 0.04 mU/mg). The contents of the thermostable ALP in the total ALP were 4.5 +/- 2.4% for controls and 3.6 +/- 2.3% for patients. To define the biochemical characteristics of the thermostable ALP, the enzyme was partially purified from a mixture of peritoneal fluid from 16 patients. The partially purified, heated ALP (PFALP) responded to the various inhibitors, activators, and pH values tested in a significantly similar manner as a purified, heated human placental ALP did. Our data suggest that PFALP may be a placental-type (or Regan) ALP.

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Condition tags

endometriosis

MeSH descriptors

Alkaline Phosphatase Ascitic Fluid Endometriosis Isoenzymes Pelvic Neoplasms Alkaline Phosphatase Alkaline Phosphatase Alkaline Phosphatase Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Enzyme Activation Enzyme Activation Female Female GPI-Linked Proteins GPI-Linked Proteins Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

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