Placental-type alkaline phosphatase in peritoneal fluid of women with endometriosis

Kang JO, Jae O. Kang, J O Kang, W A Hudak, Wayne A. Hudak, Hudak WA, W J Crowley, Crowley WJ, William Crowley, B S Criswell, Criswell BS
Clinica chimica acta; international journal of clinical chemistry · 1990 · vol. 186(2) , pp. 285–294 · doi:10.1016/0009-8981(90)90046-u · PMID:2311256 · W2026954240
article OA: closed CC0 ⤵ 5 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated placental-type alkaline phosphatase (PLAP) levels in peritoneal fluid from women with endometriosis and found it to be a potential biomarker for the condition.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Alkaline phosphatase (ALP) activities were studied in peritoneal fluid obtained from patients with untreated endometriosis and control women who had normal pelves. The patients (n = 18) had significantly higher total ALP (8.65 +/- 5.69 mU/mg, p less than 0.01) and thermostable ALP (0.28 +/- 0.23 mU/mg, p less than 0.05) than the controls (n = 7) (total ALP = 2.41 +/- 1.15; thermostable ALP = 0.09 +/- 0.04 mU/mg). The contents of the thermostable ALP in the total ALP were 4.5 +/- 2.4% for controls and 3.6 +/- 2.3% for patients. To define the biochemical characteristics of the thermostable ALP, the enzyme was partially purified from a mixture of peritoneal fluid from 16 patients. The partially purified, heated ALP (PFALP) responded to the various inhibitors, activators, and pH values tested in a significantly similar manner as a purified, heated human placental ALP did. Our data suggest that PFALP may be a placental-type (or Regan) ALP.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Alkaline Phosphatase Ascitic Fluid Endometriosis Isoenzymes Pelvic Neoplasms Alkaline Phosphatase Alkaline Phosphatase Ascitic Fluid Endometriosis Enzyme Activation Female GPI-Linked Proteins Humans Isoenzymes Isoenzymes Magnesium Magnesium Pelvic Neoplasms Placenta Placenta

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (5)

Source provenance

europepmc
last seen: 2026-09-13T09:25:22.628771+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:15.619952+00:00
unpaywall
last seen: 2026-09-13T06:26:10.529621+00:00
License: CC0 · commercial use OK