Gonadotropin releasing hormone agonist treatment for severe menorrhagia in patients with contraindications to surgery

Paolo Vercellini, Augusto Ferrari, A D’Alberton, Tiziano Motta, R Maggi, P. Molteni
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 1992 · vol. 45(1) , pp. 70–72 · doi:10.1016/0028-2243(92)90197-7 · PMID:1535604 · W2051131726
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This study investigated the efficacy of gonadotropin-releasing hormone agonist treatment for severe menorrhagia in patients who cannot undergo surgery.

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Abstract

Four patients with heavy menorrhagia, severe iron-deficiency anemia and contraindications to surgery were treated with a gonadotropin-releasing hormone agonist in a depot formulation. At 2 months of therapy they were all amenorrheic, and at 6 months the hematologic values had improved markedly. Gonadotropin-releasing hormone agonists may obviate emergency surgery in patients at high surgical risk or could constitute the first line of sequential therapeutic regimens, once general health conditions have improved.

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