Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles

Onalan G, Gogsen Onalan, Göğşen Önalan, Belgin Selam, Onalan R, Reside Onalan, Reşide Önalan, Temel Ceyhan, Ceyhan T, Mehmet Cıncık, Mehmet Cincik, Recai Pabuçcu, Pabuccu R, Recai Pabuccu
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 125(1) , pp. 85–91 · doi:10.1016/j.ejogrb.2005.08.002 · PMID:16140454 · W1993284393
article OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study investigated serum and follicular fluid levels of soluble Fas and soluble Fas ligand in women undergoing IVF to explore their potential roles in IVF outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo determine follicular fluid (FF) and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients undergoing IVF cycles.Study designA prospective comparative study among patients with endometriosis (n=12), infertility due to male factor (n=12) and poor responders (n=32) undergoing IVF cycles in Centrum IVF Clinic. Individual FF and serum samples were collected from patients during transvaginal ultrasonography-guided follicle aspiration. Patients were classified as poor responder patients undergoing IVF cycles with GnRHa, triptorelin and GnRH antagonist, cetrotide, patients with endometriosis and patients with infertility due to male factor. sFas, sFasL levels in both FF and serum samples and their correlations with clinical outcomes of IVF were measured in each study group.ResultsSerum and FF levels of sFas, sFasL were similar in the poor responder and male factor groups. There were no differences between the serum and FF levels of both sFas and sFasL among poor responder patients receiving either GnRH agonist or antagonist therapies. Serum levels of sFas were significantly lower in the endometriosis group compared to the male factor group. Serum and FF levels of sFas, sFasL were similar among patients with or without clinical pregnancy.ConclusionsFas and sFasL are detected in both serum and follicular fluid samples from IVF cycles, their levels are similar between poor responder and male factor groups as well as between GnRH agonist and antagonist treatment groups. These soluble apoptotic factors may not be predictive for the outcomes of IVF. Decreased serum levels of sFas, suggests increased apoptosis in endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

fas Receptor Fertilization in Vitro Follicular Fluid Membrane Glycoproteins Tumor Necrosis Factors Adult Endometriosis Endometriosis Fas Ligand Protein fas Receptor fas Receptor Female Follicular Fluid Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Infertility, Male Infertility, Male Male

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (48)

Cited by (2)

Source provenance

europepmc
last seen: 2026-08-09T06:10:49.860119+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:35.797702+00:00
License: CC0 · commercial use OK