OVX1 as a marker for early stage endometrial carcinoma

F J Xu, Fengji Xu, Yinhua Yu, Y H Yu, L Daly, Lisa Anselmino, L Anselmino, G M Hass, G. Michael Hass, A Berchuck, Andrew Berchuck, G C Rodriguez, Gustavo C. Rodriguez, John T. Soper, J T Soper, D L Clarke-Pearson, Daniel L. Clarke‐Pearson, Donna Hollis, D Hollis, Cinda M. Boyer, Robert C. Bast
Cancer · 1994 · vol. 73(7) , pp. 1855–1858 · doi:10.1002/1097-0142(19940401)73:7<1855::aid-cncr2820730713>3.0.co;2-# · PMID:8137210 · W2000686665
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Elevated serum OVX1 antigen was found in 64% of endometrial cancer patients, including 64% with Stage I disease, suggesting its potential as an early detection marker.

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Abstract

BACKGROUND: Endometrial carcinoma is generally diagnosed only after the onset of postmenopausal bleeding. Although most patients with Stage I disease can be cured, the prognosis worsens significantly when the tumor is no longer confined to the uterine corpus. Serum CA 125 is elevated in only 10-20% cases of Stage I and II endometrial carcinoma. A serum tumor marker that can detect early stage endometrial cancer might aid in management of the disease. METHODS: An OVX1 double-determinant radioimmunoassay was used to detect an epitope on a high-molecular-weight mucinlike glycoprotein found in the sera of 45 patients with endometrial cancer. RESULTS: Apparently healthy persons had serum OVX1 antigen levels of 2.23 plus or minus 2.48 U/ml (mean +/- standard deviation). Elevated levels of OVX1 antigen (> 7.2 U/ml) were found in 5% of 184 healthy persons and in 64% of 45 patients with endometrial cancer. OVX1 antigen was elevated in 64% of 36 patients with Stage I, 50% of 2 patients with Stage II, 60% of 5 patients with Stage III, and each of 2 patients with Stage IV endometrial cancer, but only 8.6% of 58 patients with endometriosis. Elevation of serum OVX1 was found more frequently in patients with deep myometrial invasion and with poorly differentiated tumors (P < 0.01). CONCLUSIONS: The OVX1 antigen deserves further evaluation as a marker for early detection of endometrial cancers and as a prognostic factor for women with apparent early stage disease.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Neoplasm Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Carcinoma Endometrial Neoplasms Proteins Antigens, Neoplasm Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Carcinoma Carcinoma Carcinoma Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Female Glycoproteins Humans Macrophage Colony-Stimulating Factor Macrophage Colony-Stimulating Factor

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