Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine and 1-(m-chlorophenyl) piperazine on copulatory behavior in the rat
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TFMPP and MCPP facilitated lordosis in estradiol-treated female rats while inhibiting copulatory behavior in males, indicating sex-specific effects potentially mediated by serotonin receptor activity.
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Abstract
Peripheral administrations of TFMPP (0.2- 1 mg/kg) or MCPP (1 mg/kg) facilitated lordosis behavior in female rats treated with estradiol benzoate, and had no effects in females primed with estradiol benzoate and progesterone. In contrast, TFMPP (1 mg/kg) and MCPP (1 mg/kg) inhibited copulatory behavior in male rats. It is concluded that there are sex differences in the effects of TFMPP and MCPP on copulatory behavior in the rat. Moreover, it is suggested that the effects of these drugs on copulatory behavior may be mediated by activation of 5-HT1B and/or 5-HT1C receptors, or by blockade of activity at 5-HT3 receptors.
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- W1963575053 via openalex
- W1968381363 via openalex
- W1981783120 via openalex
- W1992207507 via openalex
- W2062524946 via openalex
- W2078407571 via openalex
- W2269379976 via openalex
- W2503099426 via openalex
Cited by (1)
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- last seen: 2026-06-10T17:14:06.276822+00:00
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