The impact of periconceptional maternal stress on fecundability

Shekufe Akhter, Michele Marcus, Rich A Kerber, Rich Kerber, Maiying Kong, Kira C. Taylor
Annals of epidemiology · 2016 · vol. 26(10) , pp. 710–716.e7 · doi:10.1016/j.annepidem.2016.07.015 · PMID:27623482 · W2511469850
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This study investigated the association between periconceptional maternal stress and fecundability, finding that higher stress levels correlated with reduced chances of conception.

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Abstract

PURPOSE: To examine the association between periconceptional self-reported stress levels and fecundability in women. METHODS: Daily stress was reported on a scale from 1 to 4 (lowest to highest) among 400 women who completed daily diaries including data on lifestyle and behavioral factors, menstrual characteristics, contraceptive use, and intercourse for up to 20 cycles or until pregnancy. Discrete survival analysis was used to estimate the associations between self-reported stress during specific windows of the menstrual cycle and fecundability (cycles at risk until pregnancy), adjusting for potential confounders. RESULTS: One hundred thirty-nine women became pregnant. During the follicular phase, there was a 46% reduction in fecundability for a 1-unit increase in self-reported stress during the estimated ovulatory window (fecundability odds ratio [FOR] = 0.54; 95% confidence interval [CI] 0.35-0.84) and an attenuated trend for the preovulatory window (FOR = 0.73; 95% CI 0.48-1.10). During the luteal phase, higher stress was associated with increased probability of conception (FOR = 1.63, 95% CI 1.07-2.50), possibly due to reverse causality. CONCLUSIONS: Higher stress during the ovulatory window may reduce probability of conception; however, once conception occurs, changes in the hormonal milieu and/or knowledge of the pregnancy may result in increased stress. These findings reinforce the need for encouraging stress management techniques in the aspiring and expecting mother.

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MeSH descriptors

Pregnancy Outcome Pregnancy Rate Self Report Stress, Psychological Adult Cohort Studies Confidence Intervals Female Fertility Humans Odds Ratio Preconception Care Pregnancy Prospective Studies Severity of Illness Index Stress, Psychological Stress, Psychological United States Young Adult

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