PRE-IVF PRETREATMENT WITH A GnRH ANTAGONIST IN WOMEN WITH ENDOMETRIOSIS: CLINICAL AND REPRODUCTIVE OUTCOMES

К.О. Каримова, М.М. Максудова, У.А. Ашурова, M.B. Alieva
2026 · doi:10.5281/zenodo.22844409 · W7213668055
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This paper reviews the controversy surrounding pre-IVF pretreatment with GnRH antagonists for women with endometriosis, noting that the disease negatively impacts reproductive stages and is associated with reduced ovarian reserve.

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This paper examines the impact of endometriosis on assisted reproductive technologies, noting that the disease negatively affects folliculogenesis, oocyte competence, and embryo development. The authors highlight that these reproductive consequences are particularly severe in advanced-stage cases or when ovarian endometriomas are present, often leading to reduced ovarian reserve and lower oocyte yields during stimulation. While pre-IVF management strategies remain controversial, the text establishes the clinical context for evaluating pretreatment with GnRH antagonists. This paper is centrally about endometriosis — specifically its negative influence on IVF outcomes and the controversy surrounding pre-treatment protocols.

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Abstract

Endometriosis is a chronic estrogen-dependent inflammatory disease that affects women of reproductive age and is strongly associated with infertility. In women referred for assisted reproductive technologies (ART), endometriosis may negatively influence several stages of the reproductive process, including folliculogenesis, oocyte competence, embryo development, endometrial receptivity and implantation.[5] The reproductive consequences are particularly relevant in advanced-stage disease and in the presence of ovarian endometriomas, which may be accompanied by a reduction in ovarian reserve and a lower oocyte yield during controlled ovarian stimulation. The management of endometriosis-associated infertility before in vitro fertilization (IVF) remains controversial.
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| Endometriosis is a chronic estrogen-dependent inflammatory disease that affects women of reproductive age and is strongly associated with infertility. In women referred for assisted reproductive technologies (ART), endometriosis may negatively influence several stages of the reproductive process, including folliculogenesis, oocyte competence, embryo development, endometrial receptivity and implantation.[5] The reproductive consequences are particularly relevant in advanced-stage disease and in the presence of ovarian endometriomas, which may be accompanied by a reduction in ovarian reserve and a lower oocyte yield during controlled ovarian stimulation. The management of endometriosis-associated infertility before in vitro fertilization (IVF) remains controversial. |

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