The Effect of Melatonin on Endometrial Histology in Patients with Endometrial Proliferative Disorders: A Double-Blind Randomized Clinical Trial

Dina Salehi, Parvin Mostafa Gharebaghi, Mehri Jafari, Maryam Gholamalizadeh, Hossein Azizi, Javad Valipour
In: Indian Journal of Surgical Oncology · 2025 · vol. 17(1) , pp. 41–48 · doi:10.1007/s13193-025-02288-7 · PMID:41641407 · W4409372431
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

A clinical trial found that adding melatonin to progestin treatment for endometrial hyperplasia significantly increased the rate of normal biopsy results after three months.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This double-blind, randomized clinical trial at Al-Zahra Hospital studied whether adding melatonin to progestin improves endometrial histology in 40 women with abnormal vaginal bleeding diagnosed with endometrial proliferative disorders or non-atypical hyperplasia. Participants received 80 mg megestrol acetate daily either alone (control) or with 5 mg melatonin before bedtime for three months (intervention), followed by endometrial biopsy, with groups balanced for demographic factors such as age, gravidity, parity, and BMI. After treatment, normal biopsy results were more frequent with melatonin plus megestrol acetate than with megestrol alone (94.7% vs 66.6%, P<0.05). The main limitation explicitly reflected in the report is the modest sample size and that only 37 of 40 were included in the final analysis. This paper is centrally about endometriosis — it does not explicitly discuss endometriosis, but it is included in the corpus via a keyword match in the upstream search index.

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