Evaluating the serum levels of natural killer cells and its activating receptors in patients with Endometriosis

Dalia Tarik Kamal, Sohir Sayed, Marwa Thabet, Yossra Autify, Ahmed M. Abbas, Tarek Farghaly
In: Proceedings in Obstetrics and Gynecology · 2022 · doi:10.17077/2154-4751.31105 · W4205579533
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This study found that endometriosis patients exhibit significantly increased total natural killer cells and decreased NKp46 activity compared to healthy controls, while showing no differences in CD159a, perforin, or granzyme levels across disease stages.

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This study investigated the impact of endometriosis on peripheral blood natural killer cell frequencies and receptor expression by comparing thirty-three patients with mild, moderate, or severe disease against thirty-one healthy controls. Using flow cytometry to analyze surface markers such as CD56, CD16, NKp46, and CD159a, the researchers found a statistically significant increase in total NK cells alongside a marked decrease in the activating receptor NKp46 among those with endometriosis. The analysis revealed no significant differences between patient groups and controls regarding inhibitory receptors like CD159a or cytotoxic proteins including perforin and granzyme I. This paper is centrally about endometriosis — specifically examining the immunological profile of natural killer cells and their activating receptors in patients with the condition.

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Abstract

Natural killer cells (NK) play an importantrole causing implantation and proliferation of ectopic endometrial tissue inpatients with endometriosis. The study aims to assess the effect of endometriosison the frequency of NK cells, its activation and inhibition in the peripheral bloodof endometriotic patients.Methods:Sixty four patients are divided into twogroups: 31 healthy controls and 33 endometriosis patients divided into twosubgroups: Group (A) mild stage endometriosis and group (B) moderate and severestage endometriosis. NK cells were identified by monoclonal antibodies surfacestaining for (CD56, CD16), natural cytotoxicity receptor Nkp46, inhibitoryreceptor CD159a, perforin and granzyme using flow cytometry.  Results: There was a statistical significant increase inthe total percent of NK CD56+ in endometriosis group compared to healthy group (p=0.027). There was statisticalsignificant decrease in percentage of NKp46 in endometriosis group compared to thehealthy group (p<0.0001).  No significant difference between differentstages of the disease & control cases in CD159a, perforin and granzyme I. There was negativeCorrelation between Total NK percent and Nkp46 activity.Conclusions:there is a significantincrease in NK cells and decrease in NKp46 in endometriosis patients. Whileno difference in CD159, perforin and granzyme between patients and normal women
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Abstract

This is an accepted article with a DOI pre-assigned that is not yet published. Natural killer cells (NK) play an importantrole causing implantation and proliferation of ectopic endometrial tissue inpatients with endometriosis. The study aims to assess the effect of endometriosison the frequency of NK cells, its activation and inhibition in the peripheral bloodof endometriotic patients.

Methods

Sixty four patients are divided into twogroups: 31 healthy controls and 33 endometriosis patients divided into twosubgroups: Group (A) mild stage endometriosis and group (B) moderate and severestage endometriosis. NK cells were identified by monoclonal antibodies surfacestaining for (CD56, CD16), natural cytotoxicity receptor Nkp46, inhibitoryreceptor CD159a, perforin and granzyme using flow cytometry.

Results

There was a statistical significant increase inthe total percent of NK CD56+ in endometriosis group compared to healthy group (p=0.027). There was statisticalsignificant decrease in percentage of NKp46 in endometriosis group compared to thehealthy group (p<0.0001). No significant difference between differentstages of the disease & control cases in CD159a, perforin and granzyme I. There was negativeCorrelation between Total NK percent and Nkp46 activity. Conclusions:there is a significantincrease in NK cells and decrease in NKp46 in endometriosis patients. Whileno difference in CD159, perforin and granzyme between patients and normal women

Keywords

NK cells; Endometriosis; Infertility Publisher Notes - 21 December 2021 Dear Ahmed M. Abbas, Your manuscript, Evaluating the serum levels of natural killer cells and its activating receptors in patients with Endometriosis, # 31105, has been previewed by our Executive Editorial Board which has determined that we are unable to accept your manuscript for review. We recognize that much time and effort goes into the writing of a manuscript and that there is disappointment when a manuscript is not accepted. Thank you for submitting to Proceedings in Obstetrics and Gynecology! Susan L. Schwartz-Rogers,

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endometriosis

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