{"paper_id":"8d0ecebc-623e-479d-af2b-8db5e3f69f67","body_text":"Abstract\nThis is an accepted article with a DOI pre-assigned that is not yet published.\nNatural killer cells (NK) play an importantrole causing implantation and proliferation of ectopic endometrial tissue inpatients with endometriosis. The study aims to assess the effect of endometriosison the frequency of NK cells, its activation and inhibition in the peripheral bloodof endometriotic patients.\nMethods:\nSixty four patients are divided into twogroups: 31 healthy controls and 33 endometriosis patients divided into twosubgroups: Group (A) mild stage endometriosis and group (B) moderate and severestage endometriosis. NK cells were identified by monoclonal antibodies surfacestaining for (CD56, CD16), natural cytotoxicity receptor Nkp46, inhibitoryreceptor CD159a, perforin and granzyme using flow cytometry.\nResults:\nThere was a statistical significant increase inthe total percent of NK CD56+ in endometriosis group compared to healthy group (p=0.027). There was statisticalsignificant decrease in percentage of NKp46 in endometriosis group compared to thehealthy group (p<0.0001). No significant difference between differentstages of the disease & control cases in CD159a, perforin and granzyme I. There was negativeCorrelation between Total NK percent and Nkp46 activity.\nConclusions:there is a significantincrease in NK cells and decrease in NKp46 in endometriosis patients. Whileno difference in CD159, perforin and granzyme between patients and normal women\nKeywords: NK cells; Endometriosis; Infertility\nPublisher Notes\n- 21 December 2021 Dear Ahmed M. Abbas, Your manuscript, Evaluating the serum levels of natural killer cells and its activating receptors in patients with Endometriosis, # 31105, has been previewed by our Executive Editorial Board which has determined that we are unable to accept your manuscript for review. We recognize that much time and effort goes into the writing of a manuscript and that there is disappointment when a manuscript is not accepted. Thank you for submitting to Proceedings in Obstetrics and Gynecology! Susan L. Schwartz-Rogers,","source_license":"CC0","license_restricted":false}