Additional file 4 of Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis

Andrew Shih, Adelson, Robert P., Vashistha, Himanshu, Khalili, Houman, Nayyar, Ashima, Puran, Radha, Herrera, Rixsi, Chatterjee, Prodyot K., Lee, Annette T., Truskinovsky, Alexander M., Elmaliki, Kristine, DeFranco, Margaret, Christine N. Metz, Peter K. Gregersen
2022 · doi:10.6084/m9.figshare.21117845.v1 · W6976991139
other OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Single-cell analysis of menstrual endometrial tissue identified distinct cell clusters differentiating endometriosis cases and symptomatic individuals from controls, with uNK and B cell frequencies showing similar trends in symptomatic and case groups.

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Abstract

Additional file 4. Cell clusters of ME samples distinguish endometriosis cases and symptomatic cases vs. controls. The combined UMAP plot shown in Fig. 1 is split into controls (n = 9), cases (n = 11), and subjects with suggestive symptoms of endometriosis but without laparoscopic tissue diagnosis – the “symptomatic” group (n = 13). Comparisons of uterine NK (uNK) cell and B cell frequencies in the symptomatic group show a trend that is similar to cases vs. controls. The positive gene markers used to generate the cell clusters shown are included in Additional file 2.

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endometriosis

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last seen: 2026-05-11T08:52:30.749796+00:00
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