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Cellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics an…
BACKGROUND: Patients with endometriosis suffer with chronic pelvic pain and infertility, and from the lack of pharmacologic therapies that consistently halt disease progression. Differences in the endometrium of patients with endometriosis …
Abstract Quercetin, a flavonoid with senolytic activity, has attracted great interest as a therapy for fibrotic diseases such as pulmonary fibrosis, a disorder attributed to senescent pulmonary fibroblasts. Interestingly, quercetin has show…
Additional file 10. A reanalysis of endometriosis cases and controls after removal of one subject on hormones. The Log2 odd ratios (OR) with cell subsets enriched in controls (n=9) on the left and cell subsets enriched in cases (n=10) on th…
Additional file 10. A reanalysis of endometriosis cases and controls after removal of one subject on hormones. The Log2 odd ratios (OR) with cell subsets enriched in controls (n=9) on the left and cell subsets enriched in cases (n=10) on th…
Additional file 11. A reanalysis of stromal cells from endometriosis cases (n=10) and controls (N=9) after removal of one subject on hormones. Not surprisingly, this revised figure shows alterations in the spatial distribution of the UMAP c…
Additional file 11. A reanalysis of stromal cells from endometriosis cases (n=10) and controls (N=9) after removal of one subject on hormones. Not surprisingly, this revised figure shows alterations in the spatial distribution of the UMAP c…
Additional file 12. Stromal cells exhibit distinguishing gene markers differentially regulated in ME from endometriosis cases (n=11) and controls (n=9). Violin plots of the top 10 genes that distinguish endometriosis cases and controls with…
Additional file 12. Stromal cells exhibit distinguishing gene markers differentially regulated in ME from endometriosis cases (n=11) and controls (n=9). Violin plots of the top 10 genes that distinguish endometriosis cases and controls with…
Additional file 13. uNK cells exhibit distinguishing gene markers differentially regulated in ME from endometriosis cases and controls. Violin plots of the top 10 genes that distinguish endometriosis cases (n=11) and controls (n=9) in an an…
Additional file 13. uNK cells exhibit distinguishing gene markers differentially regulated in ME from endometriosis cases and controls. Violin plots of the top 10 genes that distinguish endometriosis cases (n=11) and controls (n=9) in an an…
Additional file 1. Comparison of UMAP plots of ME digests using fresh cells vs. methanol fixation. Virtually identical UMAP plots are observed using either fresh or methanol fixed cells from a single subject. The ME samples were prepared by…
Additional file 1. Comparison of UMAP plots of ME digests using fresh cells vs. methanol fixation. Virtually identical UMAP plots are observed using either fresh or methanol fixed cells from a single subject. The ME samples were prepared by…
Additional file 2. Markers for UMAP plots of major cell clusters.
Additional file 2. Markers for UMAP plots of major cell clusters.
Additional file 3. Cell cluster composition of ME is similar when ME is analyzed after enrichment for endometrial tissues and digested or analyzed as digested whole ME. Comparison of UMAP plots is shown for ME samples prepared by tissue enr…
Additional file 3. Cell cluster composition of ME is similar when ME is analyzed after enrichment for endometrial tissues and digested or analyzed as digested whole ME. Comparison of UMAP plots is shown for ME samples prepared by tissue enr…
Additional file 4. Cell clusters of ME samples distinguish endometriosis cases and symptomatic cases vs. controls. The combined UMAP plot shown in Fig. 1 is split into controls (n = 9), cases (n = 11), and subjects with suggestive symptoms …
Additional file 4. Cell clusters of ME samples distinguish endometriosis cases and symptomatic cases vs. controls. The combined UMAP plot shown in Fig. 1 is split into controls (n = 9), cases (n = 11), and subjects with suggestive symptoms …
Additional file 5. Top 10 genes in groups 2 and 4 stromal cell subclusters from Figs. 5 and 6.
Additional file 5. Top 10 genes in groups 2 and 4 stromal cell subclusters from Figs. 5 and 6.
Additional file 6. References for genes described in Fig. 6.
Additional file 6. References for genes described in Fig. 6.
Additional file 7. Stromal cell subclusters in ME samples map to stromal cell clusters found in first trimester decidua. We have compared the mapping of stromal subclusters reported by Vento-Tormo [26], based on the analysis of decidua in t…