Using bisphenol-a to study the onset of polycystic ovarian syndrome

1 BarontiniM.Garcia-RudazM. C.VeldhuisJ. D. (2001). Mechanisms of hypothalamic-pituitary-gonadal disruption in polycystic ovarian syndrome. Arch. Med. Res.32, 544–552. 2 BlankS. K.McCartneyC. R.HelmK. D.MarshallJ. C. (2007). Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty. Semin. Reprod. Med.25, 352–359. 3 Diamanti-KandarakisE.BourguignonJ. P.GiudiceL. C.HauserR.PrinsG. S.SotoA. M.ZoellerR. T.GoreA. C. (2009). Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev.30, 293–342. 4 EaglesonC. A.GingrichM. B.PastorC. L.AroraT. K.BurtC. M.EvansW. S.MarshallJ. C. (2000). Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J. Clin. Endocrinol. Metab.85, 4047–4052. 5 FernandezM.BianchiM.Lux-LantosV.LibertunC. (2009). Neonatal exposure to bisphenol a alters reproductive parameters and gonadotropin releasing hormone signaling in female rats. Environ. Health Perspect.117, 757–762. 6 FernandezM.BourguignonN.Lux-LantosV.LibertunC. (2010). Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats. Environ. Health Perspect.118, 1217–1222.10.1289/ehp.0901257 7 KandarakiE.ChatzigeorgiouA.LivadasS.PaliouraE.EconomouF.KoutsilierisM.PalimeriS.PanidisD.Diamanti-KandarakisE. (2011). Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J. Clin. Endocrinol. Metab.96, E480–E484. 8 RichterC. A.BirnbaumL. S.FarabolliniF.NewboldR. R.RubinB. S.TalsnessC. E.VandenberghJ. G.Walser-KuntzD. R.vom SaalF. S. (2007). In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol.24, 199–224. 9 Sotomayor-ZarateR.DorfmanM.ParedesA.LaraH. E. (2008). Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat. Biol. Reprod.78, 673–680. 10 TsutsumiR.WebsterN. J. (2009). GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr. J.56, 729–737. Summary

bisphenol A, Endocrine disrupting chemical, Fertility, GnRH, Polycystic ovarian syndrome Citation Klenke U and Hutchins BI (2011) Using Bisphenol-A to Study the Onset of Polycystic Ovarian Syndrome. Front. Endocrin. 2:12. doi: 10.3389/fendo.2011.00012 Received 31 March 2011 Accepted 29 April 2011 Published 10 May 2011 Volume 2 - 2011 Copyright © 2011 Klenke and Hutchins. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. *Correspondence: [email protected]; [email protected] †Ulrike Klenke and B. Ian Hutchins have contributed equally to this work. This article was submitted to Frontiers in Neuroendocrine Science, a specialty of Frontiers in Endocrinology. Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.