HYSTERECTOMY, HORMONES, AND BEHAVIOUR A Prospective Study

Alec Coppen
In: The Lancet · 1981 · vol. 317(8212) , pp. 126–128 · doi:10.1016/s0140-6736(81)90710-8 · PMID:6109801 · W2015513623
article OA: closed CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This prospective study investigated the relationship between hysterectomy, hormone replacement therapy, and subsequent behavioral changes in women.

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Abstract

60 premenopausal women were assessed before and after hysterectomy for menorrhagia or fibroids or both. Their mood, sexual functioning, and plasma oestrogens and gonadotrophins were regularly assessed for a period of up to 3 years. Patients were randomly assigned to receive either oestrone sulphate or placebo tablets during the trial. No evidence was found that this group of patients showed depression or sexual difficulties related to the hysterectomy. In comparison with their baseline gynaecological condition, they showed improved mood and vigour and unimpaired sexual activity.

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