Endometriose
This review discusses current understanding of endometriosis etiology, pathophysiology, and treatment, highlighting advancements in classification, diagnostics, and therapeutic strategies.
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This short narrative piece discusses endometriosis broadly, focusing on incidence variability due to differences in diagnostic accuracy and history-taking, and on how symptom severity can diverge from anatomical extent. It reviews ongoing debates about etiology and pathophysiology, mentioning classical retrograde menstruation and metaplasia theories as well as the concept of injured archimetra leading to adenomyosis, alongside speculative hypotheses such as fusiform bacteria as causes, while expressing skepticism about the plausibility of a definitive “breakthrough.” It also summarizes treatment shifts, including the impact of GnRH antagonists with add-back therapy on endometriosis-associated pain, more selective use of radical surgery for deep infiltrating disease, increased importance of operative management for peritoneal endometriosis in patients seeking children, and a cautious approach to ovarian cortex preservation for endometriomas. It notes that certain approaches, like minimal-invasive ovarian endometrioma sclerosis with high-percentage alcohol, remain uncertain and require further prospective studies. This paper is centrally about endometriosis — it provides a research-and-treatment overview emphasizing diagnostic variability, competing pathophysiologic concepts including links to adenomyosis, and evolving management strategies.
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- last seen: 2026-06-10T17:14:06.276822+00:00