Morbility Follow Up and Endocrine Disruption of Exposed Subjects

WS1-03 Abstract: We monitored (from 1976–2005) thousands of people affected by the fallout of TCDD over Seveso on July 10, 1976. Serum samples have been kept frozen and it has been possible after 1988 to measure the TCDD blood lipid content. The results indicate that: Chloracne was the only clinical alteration, which partly correlated to TCDD contamination levels with differing individual susceptibility; and Miscarriages, perinatal mortality, low birth weight, and congenital malformations did not significantly increase. Part of the exposed subjects were followed up from 1992 to 2005. The results showed that: No pathologic laboratory results were related to TCDD levels; The half-life of TCDD was longer in women (approximately 9 years) than in men (approximately 7.5 years) and much shorter in children; A doubled, nonsignificant risk for endometriosis in women was associated with serum TCDD levels of 100 ppt or higher; Among premenarcheal women, serum TCDD level was associated with a lengthening of the menstrual cycle by 0.93 days; The hazard ratio for breast cancer associated with serum TCDD levels was significantly increased to 2.1; A skewing of the sex ratio at birth with an excess of females (P < 0.001) from parents exposed to TCDD was observed and it was permanently related only to exposure of the father; and Developmental dental aberrations were registered as well associated with childhood exposure.